Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled "Health and Disease in the Retinas and Optic Nerves—for Up-to-Date Practitioners—Volume II". This is a continuation of the previous series.

Recent research indicates that many factors, including aging, genetic mutations, and the adverse effects of drugs, impact ocular tissue. These diseases are often caused by mutations encoding many different signalling and structural proteins. The effects of these diseases can be devastating, as they are often associated with several comorbidities, leading to a poor quality of life. Although many factors and mechanisms for some of these diseases have already been identified, the mechanisms regulating the development of ocular diseases are not fully understood. Further targeted research may make room for the emergence of novel therapies.

In this Special Issue, we welcome researchers and clinicians to contribute original research and review articles describing their in vivo data, as well as clinical studies, to address the mechanisms by which genetic factors and protein molecules regulate ocular disorders, as well as novel diagnostic technologies and therapies for those diseases. We will not accept a clinical report. The following topics are particularly welcome:

1. The potential effect of genetic mutations, aging, and drug side effects on eye diseases, including studies on novel mutations/biomarkers.
2. Novel technologies, such as electrophysiology, spectral domain optical coherence tomography, optical coherence tomography angiography, artificial intelligence, clinical molecular genetic tests, etc., for the diagnosis and monitoring of those eye diseases in terms of functional, morphological, and molecular characterisation.
3. Therapeutic interventions for eye diseases, including drug, surgery, stem cell, and cell and gene therapies.

Submission Guidelines:

1. Type: research article/review/communication are welcomed; for theses, we welcome retrospective/cohort/follow-up, narrative review, preliminary study, system/meta-analysis, health care/nursing, prediction/prognostic and indicators/score/scale.
2. Case studies/case series/study protocols are not considered. For mini reviews/brief reports/simple studies, wait for the pre-check approval first.
3. Not considered topics, such as clinical education, medical device/system/platform (dentistry is acceptable), cadaver study, in vitro (cell lines and with clinical significance are excluded), textbook review, medicine cost, tobacco/alcohol, 3D print of stomatology filed and without clinical application, survey or questionnaire of clinical psychology filed.
4. For a plan paper with company affiliation, if it only promotes the company product, it will be rejected; otherwise, it can be considered, and it also needs to provide conflicts of interest.

Prof. Dr. Shree K Kurup
Dr. Minzhong Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• gene
• protein
• cell
• eye
• therapy
• diagnosis

• Health and Disease in the Retinas and Optic Nerves—for Up-to-Date Practitioners in Journal of Clinical Medicine (7 articles)