Assisted Reproductive Technology: Clinical Advances and Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 August 2024 | Viewed by 866

Special Issue Editors


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Guest Editor
Gynecology and Obstetrics Unit, Department of Neurosciences, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy
Interests: ovarian reserve; antral follicle count; 3D-AFC; anti-Mullerian hormone; fertility preservation; fertility in multiple sclerosis; assisted reproductive technology; IVF pregnancy

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Guest Editor
Gynecology and Obstetrics Unit, Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy
Interests: antral follicle count; 3D-AFC; anti-Mullerian hormone; fertility preservation; endometriosis; assisted reproductive technology; reproductive endocrinology; IVF pregnancy; recurrent implantation failure; reproductive immunology

Special Issue Information

Dear Colleagues,

Nowadays, assisted reproductive technology (ART) treatments are becoming increasingly in demand, due to social reasons such as late motherhood and the improvements in the management of chronic degenerative and neoplastic disease allowing fertility preservation and family planning, among others. Therefore, many aspects of the process are continuously studied, refined and renewed to increase the chance of live birth. The aim of this Special Issue is to provide a wide overview of the recent advances in assisted reproduction, and to eventually explore the challenges of any step of the treatment, from the inclusion criteria (or diseases to consider) to allowing a couple to perform ART treatments or fertility preservation, the evaluation of the ovarian reserve (new methods such as 3D.antral follicle count), ovarian stimulation protocols (dual trigger, dual stimulation, gonadotrophin dose and type, pharmacogenomics), embryo transfer and endometrial preparation with the window of implantation and endometrial receptivity (endometrial metabolism, immunology and microbiome) and pregnancy outcomes after IVF. Hence, researchers in the field of reproductive medicine are encouraged to submit their findings as original articles or reviews to this Special Issue.

Dr. Luigi Carbone
Dr. Raffaella Di Girolamo
Guest Editors

Manuscript Submission Information

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Keywords

  • endometrial microbiome
  • endometrial receptivity
  • recurrent implantation failure
  • preimplantation genetic testing
  • artificial intelligence in ART
  • Poseidon classification
  • fertility preservation
  • immunology of reproduction
  • assisted reproductive technology
  • ovarian stimulation

Published Papers (1 paper)

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Research

15 pages, 672 KiB  
Article
Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome
by Konstantinos Sfakianoudis, Evangelos Maziotis, Anna Trypidi, Sokratis Grigoriadis, Terpsithea Vaxevanoglou, Irene Angeli, Anna Rapani, Amalia Kotsifaki, Kalliopi Pistola, Agni Pantou, Konstantinos Dafopoulos, Konstantinos Pantos and Mara Simopoulou
J. Clin. Med. 2024, 13(5), 1312; https://doi.org/10.3390/jcm13051312 - 26 Feb 2024
Viewed by 585
Abstract
Background: this study aims to assess the effect of embryo transfer (ET) performance parameters of a technical nature on IVF outcome. Methods: A total of 1417 ETs from a single IVF center were included in this prospective observational study. The parameters investigated were [...] Read more.
Background: this study aims to assess the effect of embryo transfer (ET) performance parameters of a technical nature on IVF outcome. Methods: A total of 1417 ETs from a single IVF center were included in this prospective observational study. The parameters investigated were as follows: the presence of cervical mucus post catheter withdrawal, the presence of blood, catheter reload, the employment of a tenaculum and stylet, catheter resistance as experienced by the physician and patient discomfort. Results: When ET performance parameters were associated with clinical outcomes on a singular level, none of the ET parameters presented with any statistical significance. The evaluation of covariates indicated that the number and the quality of transferred embryos, as well as maternal age, exerted a statistically significant effect on clinical outcomes. In a multivariate analysis, only the presence of mucus along with significant catheter resistance presented with statistical significance; however, when adjusting for covariates, this combination showed no statistically significant effect on clinical outcomes. Conclusions: the results indicate that the time-consuming process of recording and analyzing ET performance parameters fails to offer any additional value in predicting the cycle’s outcome, while factors like embryo quality and number, as well as maternal age, seem to be the sole robust predictive factors of an IVF cycle. Full article
(This article belongs to the Special Issue Assisted Reproductive Technology: Clinical Advances and Challenges)
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