Diagnosis and Management of Bipolar Disorder

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 10 May 2024 | Viewed by 895

Special Issue Editor


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Guest Editor
1. Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, 08036 Barcelona, Spain
2. Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova, 143, 08036 Barcelona, Spain
Interests: bipolar disorder; mental illness; clinical psychiatry; psychopharmacology

Special Issue Information

Dear Colleagues,

Bipolar disorder is a severe psychiatric disorder characterized by recurring mood episodes of depression, alternating with episodes of euphoria (called manic/hypomanic episodes) with a prevalence in the general population of 2%. While we have made advancements in understanding the biological and environmental factors contributing to bipolar disorder, its diagnosis primarily relies on clinical assessment. Additionally, while there are established pharmacological treatment guidelines, many individuals, especially those with concurrent medical or psychiatric conditions, continue to experience frequent mood swings or persistent symptoms despite being on medication. A combined approach involving systematic clinical syndrome subtyping and the examination of multiple biomarkers, such as genetics and digital markers, could better define the unique characteristics of individuals with bipolar disorder and potentially predict the course of their illness.

In this Special Issue, we extend an invitation to researchers to submit their scientific and clinical contributions focusing on various aspects of bipolar disorder diagnosis and management. We welcome cutting-edge original research, comprehensive reviews, insightful case studies, and perspectives that explore genetic and digital phenotyping, as well as emerging pharmacological and non-pharmacological interventions for this condition. We also encourage submissions related to the integration of artificial intelligence in diagnostic algorithms and strategies for managing medical comorbidities or treatment-resistant bipolar depression. Our goal is to assemble a collection of impactful works that hold clinical significance in tailoring care for individuals with bipolar disorder throughout their lifespan.

Dr. Giovanna Fico
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnostic challenges
  • biomarkers 
  • genetics 
  • digital phenotyping
  • substance abuse
  • medical comorbidities
  • personalization of care
  • treatment-resistant bipolar depression
  • artificial intelligence
  • precision medicine

Published Papers (1 paper)

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Research

11 pages, 2175 KiB  
Article
The Mixed Tendency in Bipolar Disorder: An Operational Proposal for the Integration of Mixed Episodes in Predominant Polarity
by Giovanna Fico, Gerard Anmella, Michele De Prisco, Vincenzo Oliva, Chiara Possidente, Lorenzo Bracco, Marta Bort, Tabatha Fernandez-Plaza, Anna Giménez-Palomo, Eduard Vieta and Andrea Murru
J. Clin. Med. 2023, 12(23), 7398; https://doi.org/10.3390/jcm12237398 - 29 Nov 2023
Viewed by 720
Abstract
Predominant Polarity (PP) is an established specifier of Bipolar Disorder (BD), holding significant clinical implications. Nevertheless, there exists no consensus on how to incorporate mixed states into PP, leaving patients prone to mixed recurrences that are unclassified. In a comprehensive study involving 701 [...] Read more.
Predominant Polarity (PP) is an established specifier of Bipolar Disorder (BD), holding significant clinical implications. Nevertheless, there exists no consensus on how to incorporate mixed states into PP, leaving patients prone to mixed recurrences that are unclassified. In a comprehensive study involving 701 euthymic BD patients, we sought to redefine PP by introducing a novel metric, the “mixed tendency”, and establish a practical threshold to identify patients with a “mixed phenotype”. Furthermore, we investigated potential associations between the mixed phenotype and specific PP categories. Our findings revealed that the mixed tendency correlated significantly with early BD type I, lifetime suicide attempts, self-aggressive behaviour, and lifetime number of affective episodes (>5). Using a ROC curve analysis, we determined an optimal cut-off point for the mixed tendency at 0.228, suggesting that patients with ~25% of lifetime mixed episodes relative to total affective episodes should be identified as having a mixed phenotype. Notably, the mixed phenotype was positively associated with undetermined PP and negatively with manic and depressive PP. This study introduces a promising approach to incorporating mixed episodes into the PP definition, potentially enabling tailored interventions for patients with a substantial history of mixed episodes. However, further research in large, longitudinal cohorts is essential to validate these findings. Full article
(This article belongs to the Special Issue Diagnosis and Management of Bipolar Disorder)
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