Current Applications of Contrast-Enhanced Ultrasound Imaging in Kidney Lesions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 1657

Special Issue Editors


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Guest Editor
Department of Life and Health, University of Molise "V. Tiberio", 86100 Campobasso, Italy
Interests: contrast-enhanced ultrasound; differential diagnosis; kidney cancer; testicualr cancer

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Co-Guest Editor
Department of Maternal-Child and Urological Sciences, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy
Interests: urology; uro-oncology; andrology; kidney stones; urolithiasis; incontinence; CEUS; contrast-enhanced ultrasound; kidney cancer; bladder cancer; prostate cancer; penile cancer; reflux
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Special Issue Information

Dear Colleagues,

The widespread use of abdominal imaging over the last few decades has increased the early detection of kidney lesions. Contrast-enhanced ultrasound (CEUS) allows a dynamic functional imaging of tumor perfusion, offering new diagnostic perspectives compared to traditional US B-mode or color Doppler investigation.

The advantages of using microbubble contrast agents in renal disorders have been largely documented in the literature. In 2008, CEUS was adopted by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) due to its renal indications. In fact, no approved US contrast agents have renal excretion, and renal insufficiency is not a contraindication for their use.

Moreover, recent studies showed that CEUS can be used to differentiate among lesions with an equivocal enhancement at CT or MRI, suggesting its potential role in the evaluation of renal lesions that deserve further investigation.

The present Special Issue aims to highlight the benefits of using CEUS, as a cost-effective and non-invasive method not requiring the use of ionizing radiation, in the diagnosis of kidney lesions and during the follow-up of non-surgical lesions.

Prof. Dr. Gianfranco Vallone
Guest Editor
Dr. Antonio Tufano
Co-Guest Editor

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Keywords

  • CEUS
  • kidney lesions
  • diagnosis
  • follow-up

Published Papers (1 paper)

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9 pages, 1241 KiB  
Brief Report
Qualitative Assessment of Contrast-Enhanced Ultrasound in Differentiating Clear Cell Renal Cell Carcinoma and Oncocytoma
by Antonio Tufano, Costantino Leonardo, Chiara Di Bella, Giuseppe Lucarelli, Vincenzo Dolcetti, Piervito Dipinto, Flavia Proietti, Rocco Simone Flammia, Umberto Anceschi, Sisto Perdonà, Giorgio Franco, Alessandro Sciarra, Giovanni Battista Di Pierro and Vito Cantisani
J. Clin. Med. 2023, 12(9), 3070; https://doi.org/10.3390/jcm12093070 - 23 Apr 2023
Cited by 4 | Viewed by 1399
Abstract
Background: We aimed to assess whether clear cell renal cell carcinoma (ccRCC) can be differentiated from renal oncocytoma (RO) on a contrast-enhanced ultrasound (CEUS). Methods: Between January 2021 and October 2022, we retrospectively queried and analyzed our prospectively maintained dataset. Renal mass features [...] Read more.
Background: We aimed to assess whether clear cell renal cell carcinoma (ccRCC) can be differentiated from renal oncocytoma (RO) on a contrast-enhanced ultrasound (CEUS). Methods: Between January 2021 and October 2022, we retrospectively queried and analyzed our prospectively maintained dataset. Renal mass features were scrutinized with conventional ultrasound imaging (CUS) and CEUS. All lesions were confirmed by histopathologic diagnoses after nephron-sparing surgery (NSS). A multivariable analysis was performed to identify the potential predictors of ccRCC. The area under the curve (AUC) was depicted in order to assess the diagnostic accuracy of the multivariable model. Results: A total of 126 renal masses, including 103 (81.7%) ccRCC and 23 (18.3%) RO, matched our inclusion criteria. Among these two groups, we found significant differences in terms of enhancement (homogeneous vs. heterogeneous) (p < 0.001), wash-in (fast vs. synchronous/slow) (p = 0.004), wash-out (fast vs. synchronous/slow) (p = 0.001), and rim-like enhancement (p < 0.001). On the multivariate logistic regression, heterogeneous enhancement (OR: 19.37; p = <0.001) and rim-like enhancement (OR: 3.73; p = 0.049) were independent predictors of ccRCC. Finally, these two variables had an AUC of 82.5% and 75.3%, respectively. Conclusions: Diagnostic imaging for presurgical planning is crucial in the choice of either conservative or radical management. CEUS, with its unique features, revealed its usefulness in differentiating ccRCC from RO. Full article
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