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Clinical Research Progress on the Gilles de la Tourette Syndrome
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Clinical Research Progress on the Gilles de la Tourette Syndrome

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 3399

Special Issue Editors

Prof. Dr. Marc Lavoie

E-Mail Website
Guest Editor
1. Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal, Montréal, QC H1N 3V2, Canada
2. Department of Psychiatry, University of Montreal, Montréal, QC H3T 1J4, Canada
3. Laboratoire de Psychophysiologie Cognitive et Sociale, Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal, Montréal, QC H1N 3V2, Canada
Interests: cognitive behavioral therapy; Gilles de la Tourette syndrome; neurobiology; neuropsychology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Julie B. Leclerc

E-Mail Website
Guest Editor
1. Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal, Montréal, QC H1N 3V2, Canada
2. Département de Psychologie, Université du Québec à Montréal, Montréal, QC H2X 3P2, Canada
Interests: Tourette Syndrome; Tic Disorders; tics; child and adolescent psychiatry; cognitive neuroscience; ADHD; cognitive behavioral therapy; neurodevelopmental disorders

Special Issue Information

Dear Colleagues,

We invite papers for submission to a Special Issue of the Journal of Clinical Medicine on “Clinical Research Progress on the Gilles de la Tourette Syndrome”. Multidisciplinary clinical and fundamental investigations have revolutionized the comprehension of persistent tic disorders and Gilles de la Tourette Syndrome. Studies in the field of psychology, psychiatry, neurology, neurosurgery, and many more are increasingly providing new insights into longstanding questions about tic disorders, such as 1) the development of new cognitive–behavioral therapy; 2) psychopharmacological treatment; 3) new cutting-edge treatments such as neuromodulation, deep-brain stimulation, and neurofeedback, among others.

In this Special Issue, we expect to feature the latest cutting-edge research into the evaluation and treatment of tic disorders. We also seek to emphasize conceptual frameworks that synthesize the current understanding of this field of research and suggest new outstanding questions and directions for further investigations. This Special Issue should be of interest to a broad audience interested in the treatment of tic disorders. We welcome manuscripts that examine, among others, the following research areas:

  • Psychological, psychiatric, and neurological evaluation of tic disorders;
  • Understanding tic disorders via large-scale network interactions;
  • Theoretical issues in the neurobiology of tic disorders;
  • Functional connectivity and tic symptoms;
  • Clinical evolution following cognitive–behavioral therapy;
  • The neurobiological and cognitive effect of pharmacotherapy;
  • Immunobiology and neuroimmunology;
  • Neurofeedback and biofeedback;
  • Gene–environment interactions and next-generation sequencing;
  • Brain plasticity and social environment;
  • Quality of life and clinical outcome;
  • New psychometric tools for the evaluation of tics and associated symptoms.

This Special Issue will bring together original research, reviews, and meta-analyses. Priority will be given to empirical articles reporting evaluation and treatment data. Reviews may be considered if they offer substantial new insights into important questions and issues.

Please submit a tentative title and abstract (250 words maximum) by 1 March 2023 to Marc Lavoie (marc.lavoie@umontreal.ca) or Julie Leclerc (leclerc.julie@uqam.ca). All submitted abstracts will be reviewed by June 2023, and invitations to submit complete manuscripts will be issued based on appropriateness for the Special Issue and a balance of themes. Please feel free to share this announcement with your colleagues. The full manuscript should be submitted by September 2023.

Prof. Dr. Marc Lavoie
Prof. Dr. Julie B. Leclerc
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Gilles de la Tourette Syndrome
  • tic disorders
  • provisional tic disorders
  • therapy
  • psychopharmacology
  • endocrinology
  • cognitive-behavioral treatment
  • comprehensive behavioral intervention for Tics
  • habit reversal
  • comorbidity
  • brain/anatomy and histology
  • functional connectivity
  • electroencephalography/event-related potentials
  • fMRI
  • neuropsychology
  • neurology
  • clinical psychology
  • psychophysiology

Published Papers (3 papers)

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26 pages, 2592 KiB  
Article
Comparing the ‘When’ and the ‘Where’ of Electrocortical Activity in Patients with Tourette Syndrome, Body-Focused Repetitive Behaviors, and Obsessive Compulsive Disorder
by Sarah Desfossés-Vallée, Julie B. Leclerc, Pierre Blanchet, Kieron P. O’Connor and Marc E. Lavoie
J. Clin. Med. 2024, 13(9), 2489; https://doi.org/10.3390/jcm13092489 - 24 Apr 2024
Viewed by 277
Abstract
Background/Objectives: Tourette Syndrome (TS), Obsessive Compulsive Disorder (OCD), and Body-Focused Repetitive Behaviors (BFRB) are three disorders that share many similarities in terms of phenomenology, neuroanatomy, and functionality. However, despite the literature pointing toward a plausible spectrum of these disorders, only a few [...] Read more.
Background/Objectives: Tourette Syndrome (TS), Obsessive Compulsive Disorder (OCD), and Body-Focused Repetitive Behaviors (BFRB) are three disorders that share many similarities in terms of phenomenology, neuroanatomy, and functionality. However, despite the literature pointing toward a plausible spectrum of these disorders, only a few studies have compared them. Studying the neurocognitive processes using Event-Related Potentials (ERPs) offers the advantage of assessing brain activity with excellent temporal resolution. The ERP components can then reflect specific processes known to be potentially affected by these disorders. Our first goal is to characterize ‘when’ in the processing stream group differences are the most prominent. The second goal is to identify ‘where’ in the brain the group discrepancies could be. Methods: Participants with TS (n = 24), OCD (n = 18), and BFRB (n = 16) were matched to a control group (n = 59) and were recorded with 58 EEG electrodes during a visual counting oddball task. Three ERP components were extracted (i.e., P200, N200, and P300), and generating sources were modelized with Standardized Low-Resolution Electromagnetic Tomography. Results: We showed no group differences for the P200 and N200 when controlling for anxiety and depressive symptoms, suggesting that the early cognitive processes reflected by these components are relatively intact in these populations. Our results also showed a decrease in the later anterior P300 oddball effect for the TS and OCD groups, whereas an intact oddball effect was observed for the BFRB group. Source localization analyses with sLORETA revealed activations in the lingual and middle occipital gyrus for the OCD group, distinguishing it from the other two clinical groups and the controls. Conclusions: It seems that both TS and OCD groups share deficits in anterior P300 activation but reflect distinct brain-generating source activations. Full article
(This article belongs to the Special Issue Clinical Research Progress on the Gilles de la Tourette Syndrome)
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12 pages, 291 KiB  
Article
Sex Differences in Youth with Chronic Tic Disorder and Tourette Syndrome: Evaluation of Tic Severity, Psychological Profiles, and Quality of Life
by Méliza Gagnon, Ilana Singer, Simon Morand-Beaulieu, Kieron P. O’Connor, Bruno Gauthier, Douglas W. Woods, Pierre Blanchet, Marc E. Lavoie and Julie B. Leclerc
J. Clin. Med. 2024, 13(9), 2477; https://doi.org/10.3390/jcm13092477 - 24 Apr 2024
Viewed by 702
Abstract
Background: Tourette syndrome (TS) and Chronic Tic Disorder (CT) are neurodevelopmental conditions involving motor and/or phonic tics. Youth with tics may encounter feelings of isolation, diminished self-esteem and quality of life, and academic difficulties. A growing body of scientific literature suggests sex [...] Read more.
Background: Tourette syndrome (TS) and Chronic Tic Disorder (CT) are neurodevelopmental conditions involving motor and/or phonic tics. Youth with tics may encounter feelings of isolation, diminished self-esteem and quality of life, and academic difficulties. A growing body of scientific literature suggests sex differences in youth with tics, but findings have been mixed so far. Because symptom severity peaks around puberty, understanding sex differences in tic manifestations and associated symptoms during this critical period is essential. Therefore, we aimed to assess sex differences related to tic symptoms, action planning styles, quality of life, and externalizing/internalizing symptoms in youth with tics. Methods: Our sample consisted of 66 youths with tics (19 girls) aged 7–14 (mean = 10 years). Youths were assessed with clinical interviews, as well as self- and parent-reported inventories evaluating tic symptoms, psychological profiles, and quality of life. Results: While no differences in tic symptoms were found, girls exhibited lower functional inflexibility, reduced overall functional planning effectiveness, and higher impairment in the psychological well-being subscale than boys. Additionally, girls had reduced general life satisfaction and social self-esteem. Boys reported more explosive outbursts, higher levels of hyperactivity, and more difficulties with self-concept. Conclusions: Our analyses suggested differences in several manifestations associated with tics. This introduces new perspectives that refine our understanding of sex differences. A better understanding of sex differences in tic disorders may eventually improve outcomes for all individuals living with these conditions. Full article
(This article belongs to the Special Issue Clinical Research Progress on the Gilles de la Tourette Syndrome)
12 pages, 972 KiB  
Article
Working Mechanisms of Exposure and Response Prevention in the Treatment of Tourette Syndrome and Tic Disorders Revisited: No Evidence for within-Session Habituation to Premonitory Urges
by Jolande M. T. M. van de Griendt, Nelleke M. E. van den Berg, Cara W. J. Verdellen, Daniëlle C. Cath and Marc J. P. M. Verbraak
J. Clin. Med. 2023, 12(22), 7087; https://doi.org/10.3390/jcm12227087 - 14 Nov 2023
Viewed by 1989
Abstract
Background: Exposure and response prevention (ERP) has been shown to be an effective treatment for Tourette syndrome (TS) and chronic tic disorders (CTD). ERP is based on voluntary tic suppression in combination with prolonged exposure to premonitory urges preceding tics. A prevailing hypothesis [...] Read more.
Background: Exposure and response prevention (ERP) has been shown to be an effective treatment for Tourette syndrome (TS) and chronic tic disorders (CTD). ERP is based on voluntary tic suppression in combination with prolonged exposure to premonitory urges preceding tics. A prevailing hypothesis of the working mechanism underlying ERP in tics is habituation to the premonitory urges as a result of prolonged exposure. However, results so far are equivocal. This study aims to further explore the relation between urges and ERP in tics, by investigating the course of premonitory urges during ERP sessions. Methods: Using a data-driven approach, within-session habituation to premonitory urge intensity was investigated. In total, 29 TS patients rated urge intensity at seven timepoints during ten 1 h ERP sessions. Results/Conclusions: Latent growth modeling showed an increase in urge intensity during the first 15 min of each session followed by a plateau in the remaining 45 min of the session. This does not support the idea of within-session habituation to premonitory urges as a working mechanism of ERP. Other potential underlying working mechanisms are discussed and should be tested in future research. Full article
(This article belongs to the Special Issue Clinical Research Progress on the Gilles de la Tourette Syndrome)
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