Recent Advances in Antiphospholipid Syndrome

A special issue of Immuno (ISSN 2673-5601).

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3430

Special Issue Editor

Special Issue Information

Dear colleagues,

Although guidelines of international society of thrombosis and haemostatis (ISTH) and America rheumatology association are available from several years to suggest diagnosis and treatments for primary and secondary antiphospholipid syndrome several issues are frequently debated in the daily clinical practice.

Immunomediated thrombosis recognises different pathophysiological mechanisms from traditional arterial and venous thrombosis and new pathophysiological mechanisms are recently described.

Furthermore, clinical presentation differs in young patients or adult patients, and also, therapeutic support offers different outcomes in patients with primary or secondary antiphospholipid syndrome.

Furthermore, the follow-up strategy of carriers of asymptomatic abnormal values of antiphospholipid antibodies is still debated.

Therefore, this Special Issue is dedicated to scholars that may offer their clinical and laboratory experience in the management of clinical overt antiphospholipid syndrome or asymptomatic carriers of antiphospholipid antibodies.

We think that this is still an intriguing clinical issue, and we hope that scholars around world agree.

Dr. Pierpaolo Di Micco
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Immuno is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antiphospholipid syndrome
  • antiphospholipid antibodies
  • lupus anticoagulant
  • venous thromboembolism
  • miscarriage
  • atherothrombosis

Published Papers (1 paper)

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Review

13 pages, 968 KiB  
Review
Catastrophic Antiphospholipid Syndrome: A Review
by Carmine Siniscalchi, Manuela Basaglia, Michele Riva, Michele Meschi, Tiziana Meschi, Giampiero Castaldo and Pierpaolo Di Micco
Immuno 2024, 4(1), 1-13; https://doi.org/10.3390/immuno4010001 - 25 Dec 2023
Cited by 1 | Viewed by 3045
Abstract
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic or obstetric events occurring in individuals who have persistent antiphospholipid antibodies. Catastrophic antiphospholipid syndrome (CAPS) is a rare and potentially fatal form of APS characterized by severe thrombotic complications occurring in multiple [...] Read more.
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombotic or obstetric events occurring in individuals who have persistent antiphospholipid antibodies. Catastrophic antiphospholipid syndrome (CAPS) is a rare and potentially fatal form of APS characterized by severe thrombotic complications occurring in multiple organs over a short period of time or simultaneously. CAPS is associated with a high (50%) death rate. Infections, multi-organ failure, and cerebral and heart thrombosis represent the main complications of this syndrome. Generally, anticoagulants, glucocorticoids, therapeutic plasmapheresis (TPE), and intravenous immunoglobulin (IVIG) are used in combination for treatment. Multidisciplinary care involving different specialists from hematology, rheumatology, nephrology, infectious disease, critical care, and obstetrics is often required due to the complexity of the disease. Recent data emphasize the effectiveness of biologics such as anti-TNF-a monoclonal antibodies (adalimumab, certolizumab), anti-CD38 monoclonal antibody (daratumumab), BAFF/Blys inhibitor (belimumab), and BTK inhibitor (zanubrutinib) against CAPS. In order to understand the underlying causes of CAPS, one future possibility involves investigating and characterizing the hereditary and acquired risk factors associated with CAPS. Full article
(This article belongs to the Special Issue Recent Advances in Antiphospholipid Syndrome)
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