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Venom Proteomics and Transcriptomics 2.0
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Venom Proteomics and Transcriptomics 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3865

Special Issue Editors

Prof. Dr. Edwin A. De Pauw

E-Mail Website
Guest Editor
Mass Spectrometry Laboratory (MSLab), MolSys Research Unit, University of Liège (ULiège), Allée du six août 11, 4000 Liège, Belgium
Interests: mass spectrometry; physical chemistry; biophysics
Special Issues, Collections and Topics in MDPI journals
Prof. Loïc Quinton

E-Mail Website
Guest Editor
Laboratory of Mass Spectrometry - MolSys Research Unit, Allée du six Aout 11 - Quartier Agora - B4000 -Liège 1 - Belgium
Interests: Venom toxin mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The deep analysis of venoms is receiving growing interest supported by important advances in sequencing methods, both at the nucleic acid and at the proteins/peptide level. The final toxins present in venoms can be characterized in detail, from their primary structure to their 3D fold. The level of detail that can be reached using mass spectrometry with only tiny amounts of sample opens new ways to characterize single organism toxins and to differentiate venoms from similar species of different geographical origin. The emphasis of this Special Issue will be on papers in which the methodological advances bring real breakthroughs and in which the complementarity of the approaches show a significant added value. Promising separation methods such as capillary electrophoresis and ion mobility are desired, as well as the 2D molecular mapping of venom glands by mass spectrometry imaging.

Prof. Dr. Edwin A. De Pauw
Prof. Loïc Quinton
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Toxins
  • Mass spectrometry
  • Mass spectrometry imaging
  • Hyphenated methods
  • Ion mobility
  • Capillary electrophoresis

Published Papers (1 paper)

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Review

26 pages, 501 KiB  
Review
Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders
by Sébastien Larréché, Jean-Philippe Chippaux, Lucie Chevillard, Simon Mathé, Dabor Résière, Virginie Siguret and Bruno Mégarbane
Int. J. Mol. Sci. 2021, 22(17), 9643; https://doi.org/10.3390/ijms22179643 - 06 Sep 2021
Cited by 28 | Viewed by 3145
Abstract
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of clinical and biological syndromes including local and systemic bleeding, incoagulability, thrombotic microangiopathy and macrothrombosis. Beyond hemostais disorders, toxins are also involved in the pathogenesis of edema and in most complications [...] Read more.
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of clinical and biological syndromes including local and systemic bleeding, incoagulability, thrombotic microangiopathy and macrothrombosis. Beyond hemostais disorders, toxins are also involved in the pathogenesis of edema and in most complications such as hypovolemia, cardiovascular collapse, acute kidney injury, myonecrosis, compartmental syndrome and superinfection. These toxins can be classified as enzymatic proteins (snake venom metalloproteinases, snake venom serine proteases, phospholipases A2 and L-amino acid oxidases) and non-enzymatic proteins (desintegrins and C-type lectin proteins). Bleeding is due to a multifocal toxicity targeting vessels, platelets and coagulation factors. Vessel damage due to the degradation of basement membrane and the subsequent disruption of endothelial cell integrity under hydrostatic pressure and tangential shear stress is primarily responsible for bleeding. Hemorrhage is promoted by thrombocytopenia, platelet hypoaggregation, consumption coagulopathy and fibrin(ogen)olysis. Onset of thrombotic microangiopathy is probably due to the switch of endothelium to a prothrombotic phenotype with overexpression of tissue factor and other pro-aggregating biomarkers in association with activation of platelets and coagulation. Thrombosis involving large-caliber vessels in B. lanceolatus envenomation remains a unique entity, which exact pathophysiology remains poorly understood. Full article
(This article belongs to the Special Issue Venom Proteomics and Transcriptomics 2.0)
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