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Role of the Vasculature in Neurological Disease
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Role of the Vasculature in Neurological Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (1 September 2021) | Viewed by 9045

Special Issue Editor

Prof. Dr. Mark Slevin

E-Mail Website
Guest Editor
School of Healthcare Science, Manchester Metropolitan University, Manchester, UK
Interests: angiogenesis; neurological disease; translational medicine

Special Issue Information

Dear Colleagues,

This Special Issue invites papers (reviews or original research articles) focusing on the importance of the vasculature for the function of neurological structures including the brain, spinal cord, and peripheral nervous system. The articles can discuss the therapeutic modulation of angiogenesis in neural tissue healing or the aberrant vascular production, damage, or decay in disease. Works can review our historical understanding of vasculogenesis in the context of neurological diseases and present related current and potential future therapies, including ongoing clinical trials. Novel modulators of the process of vasculogenesis, signaling data, as well as meta-analyses are also welcome. In addition, studies on the local relationships between the vasculature and other cells, for example within neurovascular units, are of interest.

Prof. Dr. Mark Slevin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • angiogenesis
  • neurological
  • stroke
  • dementia
  • regeneration
  • vascular
  • therapeutic
  • signalling
  • cancer

Published Papers (2 papers)

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Research

21 pages, 3890 KiB  
Article
Not All Lectins Are Equally Suitable for Labeling Rodent Vasculature
by Roberta Battistella, Marios Kritsilis, Hana Matuskova, Douglas Haswell, Anne Xiaoan Cheng, Anja Meissner, Maiken Nedergaard and Iben Lundgaard
Int. J. Mol. Sci. 2021, 22(21), 11554; https://doi.org/10.3390/ijms222111554 - 26 Oct 2021
Cited by 11 | Viewed by 6421
Abstract
The vascular system is vital for all tissues and the interest in its visualization spans many fields. A number of different plant-derived lectins are used for detection of vasculature; however, studies performing direct comparison of the labeling efficacy of different lectins and techniques [...] Read more.
The vascular system is vital for all tissues and the interest in its visualization spans many fields. A number of different plant-derived lectins are used for detection of vasculature; however, studies performing direct comparison of the labeling efficacy of different lectins and techniques are lacking. In this study, we compared the labeling efficacy of three lectins: Griffonia simplicifolia isolectin B4 (IB4); wheat germ agglutinin (WGA), and Lycopersicon esculentum agglutinin (LEA). The LEA lectin was identified as being far superior to the IB4 and WGA lectins in histological labeling of blood vessels in brain sections. A similar signal-to-noise ratio was achieved with high concentrations of the WGA lectin injected during intracardial perfusion. Lectins were also suitable for labeling vasculature in other tissues, including spinal cord, dura mater, heart, skeletal muscle, kidney, and liver tissues. In uninjured tissues, the LEA lectin was as accurate as the Tie2–eGFP reporter mice and GLUT-1 immunohistochemistry for labeling the cerebral vasculature, validating its specificity and sensitivity. However, in pathological situations, e.g., in stroke, the sensitivity of the LEA lectin decreases dramatically, limiting its applicability in such studies. This work can be used for selecting the type of lectin and labeling method for various tissues. Full article
(This article belongs to the Special Issue Role of the Vasculature in Neurological Disease)
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14 pages, 3704 KiB  
Article
Factors Associated with Mutations: Their Matching Rates to Cardiovascular and Neurological Diseases
by Hannah B. Lucas, Ian McKnight, Regan Raines, Abdullah Hijazi, Christoph Hart, Chan Lee, Do-Gyoon Kim, Wei Li, Peter H. U. Lee and Joon W. Shim
Int. J. Mol. Sci. 2021, 22(10), 5057; https://doi.org/10.3390/ijms22105057 - 11 May 2021
Cited by 5 | Viewed by 2167
Abstract
Monogenic hypertension is rare and caused by genetic mutations, but whether factors associated with mutations are disease-specific remains uncertain. Given two factors associated with high mutation rates, we tested how many previously known genes match with (i) proximity to telomeres or (ii) high [...] Read more.
Monogenic hypertension is rare and caused by genetic mutations, but whether factors associated with mutations are disease-specific remains uncertain. Given two factors associated with high mutation rates, we tested how many previously known genes match with (i) proximity to telomeres or (ii) high adenine and thymine content in cardiovascular diseases (CVDs) related to vascular stiffening. We extracted genomic information using a genome data viewer. In human chromosomes, 64 of 79 genetic loci involving >25 rare mutations and single nucleotide polymorphisms satisfied (i) or (ii), resulting in an 81% matching rate. However, this high matching rate was no longer observed as we checked the two factors in genes associated with essential hypertension (EH), thoracic aortic aneurysm (TAA), and congenital heart disease (CHD), resulting in matching rates of 53%, 70%, and 75%, respectively. A matching of telomere proximity or high adenine and thymine content projects the list of loci involving rare mutations of monogenic hypertension better than those of other CVDs, likely due to adoption of rigorous criteria for true-positive signals. Our data suggest that the factor–disease matching rate is an accurate tool that can explain deleterious mutations of monogenic hypertension at a >80% match—unlike the relatively lower matching rates found in human genes of EH, TAA, CHD, and familial Parkinson’s disease. Full article
(This article belongs to the Special Issue Role of the Vasculature in Neurological Disease)
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