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Silver Nanomaterials for Biological Applications

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 6921

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Prof. Dr. Brabazon Dermot

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School of Mechanical & Manufacturing Engineering, Dublin City University, D09 NA55 Dublin, Ireland
Interests: near net shape forming; laser processing; separation science technologies
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Dear Colleagues,

Silver nanoparticles are a promising zero-dimensional material that plays an important role in the diagnosis and therapy of critical ailments due to their high antibacterial and antiviral activity. When shaped in various size and morphology through different synthesis conditions, Ag NPs presents specific and genuine chemical, biological, and physical properties, which has been proved suitable for medical and biological applications.

This Special Issue welcomes original research articles and reviews articles focused on the synthesis, biocidal properties, and mechanism of action of the silver nanoparticles. Topics of interest include but are not limited to the development of antimicrobial agents, drug delivery and releasing biosensing enhancement, biomaterial, and medical device coatings, tissue restoration and regeneration materials, and performance-enhanced therapeutic alternatives.

Prof. Dr. Brabazon Dermot
Guest Editor

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Research

12 pages, 2796 KiB

Open AccessArticle

1,4-α-Glucosidase from Fusarium solani for Controllable Biosynthesis of Silver Nanoparticles and Their Multifunctional Applications

by Ying-Jie Zeng, Xiao-Ling Wu, Hui-Rong Yang, Min-Hua Zong and Wen-Yong Lou

Int. J. Mol. Sci. 2023, 24(6), 5865; https://doi.org/10.3390/ijms24065865 - 20 Mar 2023

Cited by 1 | Viewed by 1087

Abstract

In the study, monodispersed silver nanoparticles (AgNPs) with an average diameter of 9.57 nm were efficiently and controllably biosynthesized by a reductase from Fusarium solani DO7 only in the presence of β-NADPH and polyvinyl pyrrolidone (PVP). The reductase responsible for AgNP formation in F. solani DO7 was further confirmed as 1,4-α-glucosidase. Meanwhile, based on the debate on the antibacterial mechanism of AgNPs, this study elucidated in further depth that antibacterial action of AgNPs was achieved by absorbing to the cell membrane and destabilizing the membrane, leading to cell death. Moreover, AgNPs could accelerate the catalytic reaction of 4−nitroaniline, and 86.9% of 4-nitroaniline was converted to p-phenylene diamine in only 20 min by AgNPs of controllable size and morphology. Our study highlights a simple, green, and cost-effective process for biosynthesizing AgNPs with uniform sizes and excellent antibacterial activity and catalytic reduction of 4-nitroaniline. Full article

(This article belongs to the Special Issue Silver Nanomaterials for Biological Applications)

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16 pages, 3791 KiB

Open AccessArticle

Production of Silver Nano-Inks and Surface Coatings for Anti-Microbial Food Packaging and Its Ecological Impact

by N. Arul Manikandan, Ronan McCann, Dimitrios Kakavas, Keith D. Rochfort, Sithara P. Sreenilayam, Godze Alkan, Tom Stornetta, Allan Robert McGivern, Konstantinos Grintzalis, Bernd Friedrich, Greg Foley, Dermot Brabazon and Brian Freeland

Int. J. Mol. Sci. 2023, 24(6), 5341; https://doi.org/10.3390/ijms24065341 - 10 Mar 2023

Cited by 3 | Viewed by 2234

Abstract

Food spoilage is an ongoing global issue that contributes to rising carbon dioxide emissions and increased demand for food processing. This work developed anti-bacterial coatings utilising inkjet printing of silver nano-inks onto food-grade polymer packaging, with the potential to enhance food safety and reduce food spoilage. Silver nano-inks were synthesised via laser ablation synthesis in solution (LaSiS) and ultrasound pyrolysis (USP). The silver nanoparticles (AgNPs) produced using LaSiS and USP were characterised using transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, UV-Vis spectrophotometry and dynamic light scattering (DLS) analysis. The laser ablation technique, operated under recirculation mode, produced nanoparticles with a small size distribution with an average diameter ranging from 7–30 nm. Silver nano-ink was synthesised by blending isopropanol with nanoparticles dispersed in deionised water. The silver nano-inks were printed on plasma-cleaned cyclo-olefin polymer. Irrespective of the production methods, all silver nanoparticles exhibited strong antibacterial activity against E. coli with a zone of inhibition exceeding 6 mm. Furthermore, silver nano-inks printed cyclo-olefin polymer reduced the bacterial cell population from 1235 (±45) × 10⁶ cell/mL to 960 (±110) × 10⁶ cell/mL. The bactericidal performance of silver-coated polymer was comparable to that of the penicillin-coated polymer, wherein a reduction in bacterial population from 1235 (±45) × 10⁶ cell/mL to 830 (±70) × 10⁶ cell/mL was observed. Finally, the ecotoxicity of the silver nano-ink printed cyclo-olefin polymer was tested with daphniids, a species of water flea, to simulate the release of coated packaging into a freshwater environment. Full article

(This article belongs to the Special Issue Silver Nanomaterials for Biological Applications)

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15 pages, 6887 KiB

Open AccessArticle

Phytofabrication of Silver Nanoparticles Using Trigonella foenum-graceum L. Leaf and Evaluation of Its Antimicrobial and Antioxidant Activities

by Monika Moond, Sushila Singh, Seema Sangwan, Savita Rani, Anuradha Beniwal, Jyoti Rani, Anita Kumari, Indu Rani and Parvesh Devi

Int. J. Mol. Sci. 2023, 24(4), 3480; https://doi.org/10.3390/ijms24043480 - 09 Feb 2023

Cited by 4 | Viewed by 1760

Abstract

Silver nanoparticles (AgNPs) were fabricated using Trigonella foenum-graceum L. leaf extract, belonging to the variety HM 425, as leaf extracts are a rich source of phytochemicals such as polyphenols, flavonoids, and sugars, which function as reducing, stabilizing, and capping agents in the reduction of silver ions to AgNPs. These phytochemicals were quantitatively determined in leaf extracts, and then, their ability to mediate AgNP biosynthesis was assessed. The optical, structural, and morphological properties of as-synthesized AgNPs were characterized using UV-visible spectroscopy, a particle size analyzer (PSA), FESEM (field emission scanning electron microscopy), HRTEM (high-resolution transmission electron microscopy), and FTIR (Fourier transform infrared spectroscopy). HRTEM analysis demonstrated the formation of spherically shaped AgNPs with a diameter of 4–22 nm. By using the well diffusion method, the antimicrobial potency of AgNPs and leaf extract was evaluated against microbial strains of Staphylococcus aureus, Xanthomonas spp., Macrophomina phaseolina, and Fusarium oxysporum. AgNPs showed significant antioxidant efficacy with IC₅₀ = 426.25 µg/mL in comparison to leaf extract with IC₅₀ = 432.50 µg/mL against 2,2-diphenyl-1-picrylhydrazyl (DPPH). The AgNPs (64.36 mg AAE/g) demonstrated greater total antioxidant capacity using the phosphomolybdneum assay compared to the aqueous leaf extract (55.61 mg AAE/g) at a concentration of 1100 μg/mL. Based on these findings, AgNPs may indeed be useful for biomedical applications and drug delivery systems in the future. Full article

(This article belongs to the Special Issue Silver Nanomaterials for Biological Applications)

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12 pages, 3441 KiB

Open AccessArticle

Surface Engineering of AgNPs-Decorated Polyetheretherketone

by Jakub Siegel, Barbora Vyhnálková, Tatiana Savenkova, Jana Pryjmaková, Petr Slepička, Miroslav Šlouf and Tomáš Hubáček

Int. J. Mol. Sci. 2023, 24(2), 1432; https://doi.org/10.3390/ijms24021432 - 11 Jan 2023

Cited by 4 | Viewed by 1297

Abstract

Metal nanostructure-treated polymers are widely recognized as the key material responsible for a specific antibacterial response in medical-based applications. However, the finding of an optimal bactericidal effect in combination with an acceptable level of cytotoxicity, which is typical for metal nanostructures, prevents their expansion from being more significant so far. This study explores the possibility of firmly anchoring silver nanoparticles (AgNPs) into polyetherether ketone (PEEK) with a tailored surface morphology that exhibits laser-induced periodic surface structures (LIPSS). We demonstrated that laser-induced forward transfer technology is a suitable tool, which, under specific conditions, enables uniform decoration of the PEEK surface with AgNPs, regardless of whether the surface is planar or LIPSS structured. The antibacterial test proved that AgNPs-decorated LIPSS represents a more effective bactericidal protection than their planar counterparts, even if they contain a lower concentration of immobilized particles. Nanostructured PEEK with embedded AgNPs may open up new possibilities in the production of templates for replication processes in the construction of functional bactericidal biopolymers or may be directly used in tissue engineering applications. Full article

(This article belongs to the Special Issue Silver Nanomaterials for Biological Applications)

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