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Structural and Functional Characterization of Protein-Based Polymer Materials
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Structural and Functional Characterization of Protein-Based Polymer Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 10 June 2024 | Viewed by 2657

Special Issue Editors

Dr. Rong He

E-Mail Website
Guest Editor
School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China
Interests: nanomaterials based on protein and active peptide; food protein or peptide
Dr. Kunn Hadinoto Ong

E-Mail Website
Guest Editor
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore
Interests: polyelectrolytes; biological macromolecules; nanoparticle complex; drug delivery; polysaccharide; amorphous systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite the great potential and diversity of synthetic biomaterials, their applications are still limited by problems of biocompatibility, biodegradability and bioresorption. On the other hand, protein or peptide-based polymer materials have advantages in the aspects of biocompatibility, biodegradability, tunability, molecular binding ability, and bioactive properties, which demonstrate a wide potential applications in drug or nutrients delivery, food packaging, cell culture medium,cartilage tissue regeneration and 3D Biofabrication. Therefore, new strategies for preparation, structural and functional characterization of protein or peptide-based polymer materials are urgently needed. This Special Issue plans to give an overview of the most recent advances in the field of protein or peptide-based polymer materials and their applications in diverse areas. This Special Issue is aimed at providing selected contributions on advances in structural and functional characterization of protein or peptide-based polymer materials.

Dr. Rong He
Dr. Kunn Hadinoto Ong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug or nutrients delivery
  • food packaging
  • cell culture medium
  • cartilage tissue regeneration
  • 3D printing

Published Papers (1 paper)

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Research

10 pages, 2650 KiB  
Article
A Novel Homodimer Peptide–Drug Conjugate Improves the Efficacy of HER2-Positive Breast Cancer Therapy
by Shurong Liu, Ye Tian, Sujun Jiang and Zihua Wang
Int. J. Mol. Sci. 2023, 24(5), 4590; https://doi.org/10.3390/ijms24054590 - 27 Feb 2023
Cited by 4 | Viewed by 2066
Abstract
Tumor-targeting peptide–drug conjugates (PDCs) have become a focus of research in recent years. However, due to the instability of peptides and their short in vivo effective half-life, they have limited clinical application. Herein, we propose a new DOX PDC based on a homodimer [...] Read more.
Tumor-targeting peptide–drug conjugates (PDCs) have become a focus of research in recent years. However, due to the instability of peptides and their short in vivo effective half-life, they have limited clinical application. Herein, we propose a new DOX PDC based on a homodimer HER-2-targeting peptide and acid-sensitive hydrazone bond, which could enhance the anti-tumor effect of DOX and reduce systemic toxicities. The PDC could accurately deliver DOX into HER2-positive SKBR-3 cells, with it showing 2.9 times higher cellular uptake than free DOX and enhanced cytotoxicity with respect to IC50 of 140 nM (vs. 410 nM for free DOX). In vitro assays showed that the PDC had high cellular internalization efficiency and cytotoxicity. In vivo anti-tumor experiments indicated that the PDC could significantly inhibit the growth of HER2-positive breast cancer xenografts in mice and reduce the side effects of DOX. In summary, we constructed a novel PDC molecule targeting HER2-positive tumors, which may overcome some deficiencies of DOX in breast cancer therapy. Full article
(This article belongs to the Special Issue Structural and Functional Characterization of Protein-Based Polymer Materials)
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