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Advances in Nanoneurobiophysics Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3083

Special Issue Editor


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Guest Editor
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Interests: voltage and ligand gated ion channel structure and function; channelopathies; signaling transduction; G-protein coupled receptors structure and function; epilepsy and metabolism; variants and pathogenic mutations
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Special Issue Information

Dear Colleagues,

The current understanding of nanoneurobiophysics points towards the idea of merging this branch that brings together nano and medical sciences, as well as new perspectives which use nanotechnology to investigate neurodegenerative diseases in the brain. Outstanding new nanotechnologies have been developed and used in a diverse way, gaining new insights into the bimolecular cause of diseases and driving new therapies for the treatment and improvement of the morbid condition. Nanoneuroscience incorporates the study of neurodegenerative disorders using nanodevices, whereby a substantial knowledge gap needs to be filled in order to understand their mechanisms, together with nanoneurobiophysics, by bringing together nanobiomolecule research using nanostructured devices and highly sensitive approaches to conduct an in-depth investigation of the neurodegenerative disorders. Therefore, current studies in nanotechnology have consolidated its advances in biology, physics, mathematics, and chemistry. We invite applications from all sciences that incorporate nanotechnologies to search for diagnostic methods, identify neurodegenerative disease, improve treatment, and contribute to the understanding of its biological implications.

Dr. Ciria C. Hernandez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • nanodevices
  • neurodegenative diseases
  • neural network simulations
  • nanobiomolecules
  • biomaterials
  • brain imaging

Published Papers (1 paper)

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Research

18 pages, 34400 KiB  
Article
Retrograde Axonal Transport of Liposomes from Peripheral Tissue to Spinal Cord and DRGs by Optimized Phospholipid and CTB Modification
by Takafumi Fukui, Hironao Tateno, Takashi Nakamura, Yuma Yamada, Yusuke Sato, Norimasa Iwasaki, Hideyoshi Harashima and Ken Kadoya
Int. J. Mol. Sci. 2022, 23(12), 6661; https://doi.org/10.3390/ijms23126661 - 15 Jun 2022
Cited by 2 | Viewed by 2624
Abstract
Despite recent advancements in therapeutic options for disorders of the central nervous system (CNS), the lack of an efficient drug-delivery system (DDS) hampers their clinical application. We hypothesized that liposomes could be optimized for retrograde transport in axons as a DDS from peripheral [...] Read more.
Despite recent advancements in therapeutic options for disorders of the central nervous system (CNS), the lack of an efficient drug-delivery system (DDS) hampers their clinical application. We hypothesized that liposomes could be optimized for retrograde transport in axons as a DDS from peripheral tissues to the spinal cord and dorsal root ganglia (DRGs). Three types of liposomes consisting of DSPC, DSPC/POPC, or POPC in combination with cholesterol (Chol) and polyethylene glycol (PEG) lipid were administered to sciatic nerves or the tibialis anterior muscle of mature rats. Liposomes in cell bodies were detected with infrared fluorescence of DiD conjugated to liposomes. Three days later, all nerve-administered liposomes were retrogradely transported to the spinal cord and DRGs, whereas only muscle-administered liposomes consisting of DSPC reached the spinal cord and DRGs. Modification with Cholera toxin B subunit improved the transport efficiency of liposomes to the spinal cord and DRGs from 4.5% to 17.3% and from 3.9% to 14.3% via nerve administration, and from 2.6% to 4.8% and from 2.3% to 4.1% via muscle administration, respectively. Modification with octa-arginine (R8) improved the transport efficiency via nerve administration but abolished the transport capability via muscle administration. These findings provide the initial data for the development of a novel DDS targeting the spinal cord and DRGs via peripheral administration. Full article
(This article belongs to the Special Issue Advances in Nanoneurobiophysics Research)
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