Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.8
5.6
Journals
IJMS
Special Issues
Metabolism Signaling and Gene Regulation in Human Health
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Metabolism Signaling and Gene Regulation in Human Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 13896

Special Issue Editor

Dr. Prasanth Puthanveetil

E-Mail Website
Guest Editor
Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, IL 60515, USA
Interests: metabolism; metabolic signaling; drug targets; immunopharmacology; infections; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,
 

Substrates bring about cellular changes by triggering signaling networks and through the regulation of specific genes required to adapt and survive a specific physiological state, which is apparent when a cell is exposed to either over nutritional or under nutritional state. In addition, various pathological states like insulin resistance, obesity, diabetes, cancer, and neurodegeneration will impact the ability of cells to handle the nutrients. Proteins from the membrane surface to other major cellular compartments like cytosol, mitochondria, and the nucleus coordinate normal cellular functions. A lack of coordination leads to disease state due to various triggers.

As a sincere attempt to gain an in depth understanding of all the major metabolic states, we are interested in receiving works in categories including original and review article types that encompass metabolic signaling and gene regulation under various states. These include healthy state, during short and long-term fasting, during exercise, and disease states like diabetes, obesity, insulin resistance, ischemia, infection, inflammation, cancer, and neurodegeneration. How metabolic signaling and gene regulation will be altered in health and disease states will be the major focus.

We anticipate having your outstanding contribution in this Special Issue.

Dr. Prasanth Puthanveetil
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolism
  • metabolic stress
  • metabolism and normal physiology
  • metabolism and disease states
  • metabolic dysfunction and gene regulation

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 5450 KiB  
Article
Exosome Degeneration in Mesenchymal Stem Cells Derived from Patients with Type 1 Diabetes Mellitus
by Michiko Horiguchi, Yuko Okada, Yuya Turudome and Kentaro Ushijima
Int. J. Mol. Sci. 2021, 22(20), 10906; https://doi.org/10.3390/ijms222010906 - 09 Oct 2021
Cited by 5 | Viewed by 2036
Abstract
Type 1 diabetes mellitus is characterized by the destruction of pancreatic β-cells and requires the regeneration of these destroyed pancreatic β-cells for radical treatment. The degeneration of organelles in stem cells compromises stem cell quality; however, organelles in the mesenchymal stem cells of [...] Read more.
Type 1 diabetes mellitus is characterized by the destruction of pancreatic β-cells and requires the regeneration of these destroyed pancreatic β-cells for radical treatment. The degeneration of organelles in stem cells compromises stem cell quality; however, organelles in the mesenchymal stem cells of patients with type 1 diabetes mellitus have not been characterized previously. In this study, we use transmission electron microscopy to evaluate the degeneration of organelles in adipose-derived stem cells of patients with type 1 diabetes mellitus (T1DM ADSCs). Compared to adipose-derived stem cells from healthy humans, T1DM ADSCs degenerate differently, characterized by prominent enlarged spherical vesicles. The exosomes of T1DM ADSCs are found to be enlarged, reduced in number, and increased in the percentage of those positive for tetraspanin CD9. The findings of this study provide insight into the characteristics of stem cells in patients with type 1 diabetes mellitus. Full article
(This article belongs to the Special Issue Metabolism Signaling and Gene Regulation in Human Health)
►▼ Show Figures

Figure 1

14 pages, 3704 KiB  
Article
The Transplantation Resistance of Type II Diabetes Mellitus Adipose-Derived Stem Cells Is Due to G6PC and IGF1 Genes Related to the FoxO Signaling Pathway
by Michiko Horiguchi, Yuya Turudome and Kentaro Ushijima
Int. J. Mol. Sci. 2021, 22(12), 6595; https://doi.org/10.3390/ijms22126595 - 19 Jun 2021
Cited by 4 | Viewed by 2108
Abstract
In cases of patients with rapidly progressive diabetes mellitus (DM), autologous stem cell transplantation is considered as one of the regenerative treatments. However, whether the effects of autonomous stem cell transplantation on DM patients are equivalent to transplantation of stem cells derived from [...] Read more.
In cases of patients with rapidly progressive diabetes mellitus (DM), autologous stem cell transplantation is considered as one of the regenerative treatments. However, whether the effects of autonomous stem cell transplantation on DM patients are equivalent to transplantation of stem cells derived from healthy persons is unclear. This study revealed that adipose-derived mesenchymal stem cells (ADSC) derived from type II DM patients had lower transplantation efficiency, proliferation potency, and stemness than those derived from healthy persons, leading to a tendency to induce apoptotic cell death. To address this issue, we conducted a cyclopedic mRNA analysis using a next-generation sequencer and identified G6PC3 and IGF1, genes related to the FoxO signaling pathway, as the genes responsible for lower performance. Moreover, it was demonstrated that the lower transplantation efficiency of ADSCs derived from type II DM patients might be improved by knocking down both G6PC3 and IGF1 genes. This study clarified the difference in transplantation efficiency between ADSCs derived from type II DM patients and those derived from healthy persons and the genes responsible for the lower performance of the former. These results can provide a new strategy for stabilizing the quality of stem cells and improving the therapeutic effects of regenerative treatments on autonomous stem cell transplantation in patients with DM. Full article
(This article belongs to the Special Issue Metabolism Signaling and Gene Regulation in Human Health)
►▼ Show Figures

Figure 1

Review

Jump to: Research

10 pages, 1275 KiB  
Review
Galectin-2 in Health and Diseases
by Muhammed N. Negedu, Carrie A. Duckworth and Lu-Gang Yu
Int. J. Mol. Sci. 2023, 24(1), 341; https://doi.org/10.3390/ijms24010341 - 25 Dec 2022
Cited by 6 | Viewed by 1891
Abstract
Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has [...] Read more.
Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has been reported to contribute to the strength of the mucus layer, protect the integrity of epithelia. A number of studies have also suggested the involvement of galectin-2 in tissue inflammation, immune response and cell apoptosis. Alteration of galectin-2 expression occurs in inflammatory bowel disease, coronary artery diseases, rheumatoid arthritis, cancer, and pregnancy disorders and has been shown to be involved in disease pathogenesis. This review discusses our current understanding of the role and actions of galectin-2 in regulation of these pathophysiological conditions. Full article
(This article belongs to the Special Issue Metabolism Signaling and Gene Regulation in Human Health)
►▼ Show Figures

Figure 1

27 pages, 1836 KiB  
Review
Connexins and Glucose Metabolism in Cancer
by Jennifer C. Jones and Thomas M. Bodenstine
Int. J. Mol. Sci. 2022, 23(17), 10172; https://doi.org/10.3390/ijms231710172 - 05 Sep 2022
Cited by 4 | Viewed by 3617
Abstract
Connexins are a family of transmembrane proteins that regulate diverse cellular functions. Originally characterized for their ability to mediate direct intercellular communication through the formation of highly regulated membrane channels, their functions have been extended to the exchange of molecules with the extracellular [...] Read more.
Connexins are a family of transmembrane proteins that regulate diverse cellular functions. Originally characterized for their ability to mediate direct intercellular communication through the formation of highly regulated membrane channels, their functions have been extended to the exchange of molecules with the extracellular environment, and the ability to modulate numerous channel-independent effects on processes such as motility and survival. Notably, connexins have been implicated in cancer biology for their context-dependent roles that can both promote or suppress cancer cell function. Moreover, connexins are able to mediate many aspects of cellular metabolism including the intercellular coupling of nutrients and signaling molecules. During cancer progression, changes to substrate utilization occur to support energy production and biomass accumulation. This results in metabolic plasticity that promotes cell survival and proliferation, and can impact therapeutic resistance. Significant progress has been made in our understanding of connexin and cancer biology, however, delineating the roles these multi-faceted proteins play in metabolic adaptation of cancer cells is just beginning. Glucose represents a major carbon substrate for energy production, nucleotide synthesis, carbohydrate modifications and generation of biosynthetic intermediates. While cancer cells often exhibit a dependence on glycolytic metabolism for survival, cellular reprogramming of metabolic pathways is common when blood perfusion is limited in growing tumors. These metabolic changes drive aggressive phenotypes through the acquisition of functional traits. Connections between glucose metabolism and connexin function in cancer cells and the surrounding stroma are now apparent, however much remains to be discovered regarding these relationships. This review discusses the existing evidence in this area and highlights directions for continued investigation. Full article
(This article belongs to the Special Issue Metabolism Signaling and Gene Regulation in Human Health)
►▼ Show Figures

Figure 1

20 pages, 774 KiB  
Review
The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems
by Monica Misch and Prasanth Puthanveetil
Int. J. Mol. Sci. 2022, 23(10), 5439; https://doi.org/10.3390/ijms23105439 - 13 May 2022
Cited by 11 | Viewed by 3268
Abstract
Leptin is a well-known hunger-sensing peptide hormone. The role of leptin in weight gain and metabolic homeostasis has been explored for the past two decades. In this review, we have tried to shed light upon the impact of leptin signaling on health and [...] Read more.
Leptin is a well-known hunger-sensing peptide hormone. The role of leptin in weight gain and metabolic homeostasis has been explored for the past two decades. In this review, we have tried to shed light upon the impact of leptin signaling on health and diseases. At low or moderate levels, this peptide hormone supports physiological roles, but at chronically higher doses exhibits detrimental effects on various systems. The untoward effects we observe with chronically higher levels of leptin are due to their receptor-mediated effect or due to leptin resistance and are not well studied. This review will help us in understanding the non-anorexic roles of leptin, including their contribution to the metabolism of various systems and inflammation. We will be able to get an alternative perspective regarding the physiological and pathological roles of this mysterious peptide hormone. Full article
(This article belongs to the Special Issue Metabolism Signaling and Gene Regulation in Human Health)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop