The Physiology and Pathophysiology of the Erythrocyte
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (14 July 2023) | Viewed by 2467
Special Issue Editors
Interests: erythrocyte; hypoxia; deoxyhemoglobin; molecular switch; metabolic shift; mechanotransduction; ion transport; oxidative stress; eryptosis; microvascular autoregulation
Special Issues, Collections and Topics in MDPI journals
2. Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada
Interests: erythrocyte; hypoxia; microvascular oxygen transport; microvascular autoregulation of oxygen supply
Special Issue Information
Dear Colleagues,
The multifunctional erythrocyte is central to matching oxygen supply, via the microcirculation, to tissue oxygen demand, generated by mitochondrial oxidative phosphorylation, as well as the removal of CO2 from tissues. Due to its constantly changing oxygen microenvironment, both erythrocyte membranes and proteins are highly susceptible to oxidative damage, necessitating elaborate antioxidant capacity and clearance mechanisms via vesiculation and cell suicide. In addition to transporting O2, CO2 and NO gases and releasing vasodilatory molecules in response to hypoxia, the erythrocyte also modulates immune, clotting and inflammatory reactions.
In this conceptual Journal Series, we are interested in the following questions regarding erythrocyte physiology and pathophysiology at the molecular level:
- How does the erythrocyte “sense” and respond to hypoxic environments?
- How does the erythrocyte “sense” and respond to mechanical forces that impinge on it as it flows through the vasculature?
- How does the erythrocyte protect itself from oxidative stresses and how are damaged RBCs processed and removed from the circulation?
- How does the erythrocyte signal the vascular endothelium and what is its relationship with the microcirculation in terms of O2 autoregulation?
- What roles do erythrocytes play in the immune and inflammatory responses?
- What effects do blood storage or a range of diseases such as sickle-cell disease, xerocytosis, sepsis, diabetes and COVID-19 have on erythrocyte physiology and function.
Submissions, including original research reports, reviews, and letters dealing with these questions are welcome.
Dr. Ryon M. Bateman
Prof. Dr. Christopher Ellis
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- erythrocyte
- hypoxia
- deoxyhemoglobin
- molecular switch
- metabolic shift
- mechanotransduction
- ion transport
- oxidative stress
- eryptosis
- microvascular autoregulation