Advances in Epigenome Editing
Deadline for manuscript submissions: closed (17 November 2019) | Viewed by 37174
Interests: DNA methyltransferases; DNA methylation; protein methyltransferases; protein methylation; reading domains; molecular epigenetics; synthetic biology; molecular enzymology
Special Issues, Collections and Topics in MDPI journals
Interests: epigenome editing; DNA methylation; chromatin marks; molecular epigenetics; molecular genetics; imprinting
In the last decade, epigenome editing, the locus of specific rewriting of epigenetic information, has been identified as an emerging key technology in basic research in molecular biology and molecular genetics. It has great promise in the field of molecular medicine, where it could help to up- or downregulate disease-associated genes in a durable manner, providing one step towards the aim of causative therapy. Epigenome editing can be achieved by the expression of artificial fusion proteins in the target cell comprinsing one part guiding the proteins to genomic target loci and another part rewriting chromatin marks at the target site. In this Special Issue of the International Journal of Molecular Sciences, the concepts and applications of epigenome editing are presented at the intersection of molecular epigenetics, biochemistry, and synthetic biology. Potential topics include but are not limited to design of enzymes applied in epigenome editing, genome targeting methods, design of dCas variants with improved properties, specificity and stability of epigenome editing as well as delivery methods of epigenome editors and their regulation. Review articles and primary papers are equally welcome, but topics of reviews should be prearranged with the editors. Publishing a paper in this Issue will present your work in the context of related papers written by other leaders of the field and thus maximize the visibility and impact of your work.
The International Journal of Molecular Sciences is an international, peer-reviewed, open-access journal providing an advanced forum for biochemistry, molecular and cell biology, and molecular biophysics, and is published semi-monthly online by MDPI. The Australian Society of Plant Scientists (ASPS) and Epigenetics Society are affiliated with IJMS. The journal was established in 2000 and has an impact factor of 3.687.
Prof. Dr. Albert Jeltsch
Dr. Pavel Bashtrykov
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- TET enzyme
- Histone lysine methyltransferase
- Histone lysine demethylase
- Histone lysine acetyltransferase
- Histone deacetylase
- Specificity of epigenome editing
- Stability of epigenome editing
- Delivery of epigenome editors
- Design of epigenome editors
- Regulation of epigenome editors