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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 8971

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Prof. Dr. Feng-Huei Lin

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Institute of Biomedical Engineering and Nano-Medicine, National Health Research Institutes, Miaoli County 35053, Taiwan
Interests: biomaterials; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The present Special Issue focuses on the “Translation of Cells, Nanomaterials and Signaling Molecules into Regenerative Medicine”, highlighting the current state and future prospects of the new generation of multifunctional bio-nanomaterials, based on organic and inorganic nanostructures and different natural or synthetic biopolymers/ceramics, for tissue engineering and regeneration applications. The impact of nanotechnology has helped to improve the efficacy of available therapeutics with the possibility to control specific cell functions by modulating material properties. Nanotechnology enables the development of new systems that mimic the complex, hierarchical structure of the native tissue. The confluence of nanotechnology and biology can address several biomedical problems and revolutionize the field of health and medicine.

Regenerative medicine requires functional/physical platforms, scaffolds with specific properties concerning the morphology, chemistry of the surface, and interconnectivity to promote cell adhesion and proliferation. This Special Issue is focused on nanomaterial synthesis, development, and characterization, with specific attention paid to the correlation between material properties and stem cell interactions. In particular, contributions focused on polymeric/ceramic nanocomposites, nanotopography, and nanoparticles will be considered, which promise an exciting future at the interface of chemistry, biology, and material science.

Prof. Dr. Feng-Huei Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanomedicine
nanotechnology
nanomaterial synthesis
microfluidics
tissue engineering
regenerative medicine
stem cell
biomaterial

Published Papers (5 papers)

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Research

25 pages, 6391 KiB

Open AccessArticle

Mutant-Dependent Local Orientational Correlation in Biofilms of Vibrio campbellii Revealed through Digital Processing of Light Microscopy Images

by Maura Cesaria, Matteo Calcagnile, Pietro Alifano and Rosella Cataldo

Int. J. Mol. Sci. 2023, 24(6), 5423; https://doi.org/10.3390/ijms24065423 - 12 Mar 2023

Cited by 1 | Viewed by 1254

Abstract

Biofilms are key bacterial communities in genetic and adaptive resistance to antibiotics as well as disease control strategies. The mature high-coverage biofilm formations of the Vibrio campbellii strains (wild type BB120 and isogenic derivatives JAF633, KM387, and JMH603) are studied here through the unstraightforward digital processing of morphologically complex images without segmentation or the unrealistic simplifications used to artificially simulate low-density formations. The main results concern the specific mutant- and coverage-dependent short-range orientational correlation as well as the coherent development of biofilm growth pathways over the subdomains of the image. These findings are demonstrated to be unthinkable based only on a visual inspection of the samples or on methods such as Voronoi tessellation or correlation analyses. The presented approach is general, relies on measured rather than simulated low-density formations, and could be employed in the development of a highly efficient screening method for drugs or innovative materials. Full article

(This article belongs to the Special Issue Bio-Engineering and Nano-Medicine 2.0)

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10 pages, 2686 KiB

Open AccessArticle

High–Performance Biscrolled Ni–Fe Yarn Battery with Outer Buffer Layer

by Jin Hyeong Choi, Juwan Kim, Jun Ho Noh, Gyuyoung Lee, Chaewon Yoon, Ui Chan Kim, In Hyeok Jang, Hae Yong Kim and Changsoon Choi

Int. J. Mol. Sci. 2023, 24(2), 1067; https://doi.org/10.3390/ijms24021067 - 05 Jan 2023

Viewed by 1244

Abstract

The increasing demand for portable and wearable electronics has promoted the development of safe and flexible yarn–based batteries with outstanding electrochemical properties. However, achieving superior energy storage performance with a high active material (AM) load and long cycle life with this device format remains a challenge. In this study, a stable and rechargeable high–performance aqueous Ni–Fe yarn battery was constructed via biscrolling to embed AMs within helical carbon nanotube (CNT) yarn corridors. Owing to the high load of charge storage nanoparticles (NPs; above 97 wt%) and the outer neat CNT layer, the buffered biscrolled Ni–Fe yarn battery demonstrates excellent linear capacity (0.053 mAh/cm) and cycling stability (60.1% retention after 300 charge/discharge cycles) in an aqueous electrolyte. Moreover, our flexible yarn battery exhibits maximum energy/power densities of 422 mWh/cm³ and 7535 mW/cm³ based on the total volume of the cathode and anode, respectively, which exceed those reported for many flexible Ni–Fe batteries. Thus, biscrolled Ni–Fe yarn batteries are promising candidates for next–generation conformal energy solutions. Full article

(This article belongs to the Special Issue Bio-Engineering and Nano-Medicine 2.0)

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10 pages, 3760 KiB

Open AccessArticle

Quantitative Analysis of Collective Migration by Single-Cell Tracking Aimed at Understanding Cancer Metastasis

by Zhuohan Xin, Keiko Deguchi, Shin-ichiro Suye and Satoshi Fujita

Int. J. Mol. Sci. 2022, 23(20), 12372; https://doi.org/10.3390/ijms232012372 - 15 Oct 2022

Cited by 2 | Viewed by 1611

Abstract

Metastasis is a major complication of cancer treatments. Studies of the migratory behavior of cells are needed to investigate and control metastasis. Metastasis is based on the epithelial–mesenchymal transition, in which epithelial cells acquire mesenchymal properties and the ability to leave the population to invade other regions of the body. In collective migration, highly migratory “leader” cells are found at the front of the cell population, as well as cells that “follow” these leader cells. However, the interactions between these cells are not well understood. We examined the migration properties of leader–follower cells during collective migration at the single-cell level. Different mixed ratios of “leader” and “follower” cell populations were compared. Collective migration was quantitatively analyzed from two perspectives: cell migration within the colony and migration of the entire colony. Analysis of the effect of the cell mixing ratio on migration behavior showed that a small number of highly migratory cells enhanced some of the migratory properties of other cells. The results provide useful insights into the cellular interactions in collective cell migration of cancer cell invasion. Full article

(This article belongs to the Special Issue Bio-Engineering and Nano-Medicine 2.0)

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19 pages, 5929 KiB

Open AccessArticle

A Polysaccharide Isolated from the Herb Bletilla striata Combined with Methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing

by Subhaini Jakfar, Tzu-Chieh Lin, Zhi-Yu Chen, I-Hsuan Yang, Basri A. Gani, Diana Setya Ningsih, Hendra Kusuma, Chia-Tien Chang and Feng-Huei Lin

Int. J. Mol. Sci. 2022, 23(19), 12019; https://doi.org/10.3390/ijms231912019 - 10 Oct 2022

Cited by 13 | Viewed by 2695

Abstract

The Bletilla striata Polysaccharide (BSP), a natural polysaccharide derived from the east Asian terrestrial orchid Bletilla striata, is an anti-inflammatory, antiviral, and antioxidant polysaccharide. Traditionally, it has been used to treat hemostasis and for wound healing. In this study, BSP was blended with methylcellulose (MC) and methylparaben (MP) to create a hydrogel through a self-assembly route as a wound dressing. The developed hydrogels were designed as M2Bx, M5Bx, and M8Bx. M stands for MC, and the number represents a percentage. Whereas the second letter of B stands for BSP, and x refers to the percentage variation of BSP: x = 0.5%, 1%, and 2%. All the developed MB hydrogels contained β-glucopyranosyl and α-mannopyranosyl, and rheology test had a tan δ value ≥ 0.5. The pore sizes of the hydrogels decreased by increasing the MC and BSP content, and they had better properties with respect to water loss and their swelling ratio. Evaluations in vitro and in vivo showed that all of the developed MB hydrogels have good cell viability and wound-healing properties. The M8B2 hydrogel group was found to be superior to the others from within the developed MB hydrogels. Therefore, we believe that the M8B2 hydrogel formulation has a high potential for development as a wound dressing. Full article

(This article belongs to the Special Issue Bio-Engineering and Nano-Medicine 2.0)

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25 pages, 6390 KiB

Open AccessArticle

Neuroprotective Effect of Gold Nanoparticles and Alpha-Lipoic Acid Mixture against Radiation-Induced Brain Damage in Rats

by Noha F. Abdelkader, Ahmed I. El-Batal, Yara M. Amin, Asrar M. Hawas, Seham H. M. Hassan and Nihad I. Eid

Int. J. Mol. Sci. 2022, 23(17), 9640; https://doi.org/10.3390/ijms23179640 - 25 Aug 2022

Cited by 5 | Viewed by 1604

Abstract

The current study aims to evaluate the possible neuroprotective impact of gold nanoparticles (AuNPs) and an alpha-lipoic acid (ALA) mixture against brain damage in irradiated rats. AuNPs were synthesized and characterized using different techniques. Then, a preliminary investigation was carried out to determine the neuroprotective dose of AuNPs, where three single doses (500, 1000, and 1500 µg/kg) were orally administrated to male Wistar rats, one hour before being exposed to a single dose of 7Gy gamma radiation. One day following irradiation, the estimation of oxidative stress biomarkers (malondialdehyde, MDA; glutathione peroxidase, GPX), DNA fragmentation, and histopathological alterations were performed in brain cortical and hippocampal tissues in both normal and irradiated rats. The chosen neuroprotective dose of AuNPs (1000 µg/kg) was processed with ALA (100 mg/kg) to prepare the AuNPs-ALA mixture. The acute neuroprotective effect of AuNPs-ALA in irradiated rats was determined against valproic acid as a neuroprotective centrally acting reference drug. All drugs were orally administered one hour before the 7Gy-gamma irradiation. One day following irradiation, animals were sacrificed and exposed to examinations such as those of the preliminary experiment. Administration of AuNPs, ALA, and AuNPs-ALA mixture before irradiation significantly attenuated the radiation-induced oxidative stress through amelioration of MDA content and GPX activity along with alleviating DNA fragmentation and histopathological changes in both cortical and hippocampal tissues. Notably, the AuNPs-ALA mixture showed superior effect compared to that of AuNPs or ALA alone, as it mitigated oxidative stress, DNA damage, and histopathological injury collectively. Administration of AuNPs-ALA resulted in normalized MDA content, increased GPX activity, restored DNA content in the cortex and hippocampus besides only mild histopathological changes. The present data suggest that the AuNPs-ALA mixture may be considered a potential candidate for alleviating radiation-associated brain toxicity. Full article

(This article belongs to the Special Issue Bio-Engineering and Nano-Medicine 2.0)

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