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From Molecular Interactions to Cellular Metabolisms in Drosophila

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3469

Special Issue Editors


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Guest Editor
Department of Biomolecular Engineering, Kyoto Institute of Technology, Kyoto 606-8585, Japan
Interests: natural substance; analytical biochemistry; microbiology; lipid metabolism

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Guest Editor
Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan
Interests: drosophila; lipid metabolism; development; immunology

Special Issue Information

Dear Colleagues,

The physiological functions of cells or regulation of their development, which are well conserved from invertebrates to vertebrates, are controlled by many molecular and cellular mechanisms. The molecular interactions are essential to understand the function and characterization of protein and/or predict the biological processes.

Currently, some models have been used for over a century as model organisms for investigating molecular interactions, such as yeast, nematode, zebrafish, and the fruit fly. However, Drosophila melanogaster constitutes an excellent experimental model for studying various aspects of biological issues, as many of its biological and physiological properties are conserved with those of mammals, and it exhibits functional homology with nearly 75% of human disease-causing genes. This model is also advantageous as flies are easily genetically manipulated and have a short lifespan. Moreover, established libraries of Drosophila mutants and transgenes, as well as transgenic and reporter lines are available. It also has many characteristics which make it an ideal organism for the study of animal development.

In this Special Issue, we will recruit original articles and reviews that provide novel insights into the molecular interactions/cells metabolism in Drosophila.

Prof. Kaeko Kamei
Dr. Binh Tran Duy
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • drosophila model
  • molecular interaction
  • cell metabolism
  • development
  • cell cycle control
  • human disease

Published Papers (1 paper)

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Research

11 pages, 1772 KiB  
Article
Role of Serotonin Transporter in Eye Development of Drosophila melanogaster
by Tuan L. A. Pham, Tran Duy Binh, Guanchen Liu, Thanh Q. C. Nguyen, Yen D. H. Nguyen, Ritsuko Sahashi, Tran Thanh Men and Kaeko Kamei
Int. J. Mol. Sci. 2020, 21(11), 4086; https://doi.org/10.3390/ijms21114086 - 8 Jun 2020
Cited by 3 | Viewed by 2812
Abstract
Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in Drosophila melanogaster [...] Read more.
Serotonin transporter (SerT) in the brain is an important neurotransmitter transporter involved in mental health. However, its role in peripheral organs is poorly understood. In this study, we investigated the function of SerT in the development of the compound eye in Drosophila melanogaster. We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. Furthermore, the knockdown of SerT in the eye disc suppressed the activation of Akt, and the introduction of PI3K effectively rescued this phenotype. These results suggested that SerT plays a role in the healthy eye development of D. melanogaster by controlling cell death through the regulation of the PI3K/Akt pathway. Full article
(This article belongs to the Special Issue From Molecular Interactions to Cellular Metabolisms in Drosophila)
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