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Biomaterials for Dental Applications and Implants
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Biomaterials for Dental Applications and Implants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 3709

Special Issue Editors

Prof. Dr. Majeed Rana

E-Mail Website
Guest Editor
Department of Oral and Maxillofacial Surgery, University of Duesseldorf, Moorenstr 5, D-40225 Dusseldorf, Germany
Interests: computer-aided design (CAD) and manufacturing (CAM); computer assisted surgery (CAS); patient specific implants (PSI)
Special Issues, Collections and Topics in MDPI journals
Dr. Lara K. F. Schorn

E-Mail Website
Co-Guest Editor
Department of Oral & Maxillofacial Surgery, University of Duesseldorf, Moorenstr 5, D-40225 Dusseldorf, Germany
Interests: bone augmentation; 3-D bioprinting; CAD/CAM Techniques; biomaterials; patient-specific implants

Special Issue Information

Dear Colleagues,

In oral and maxillofacial surgery computer assisted surgery as well as planning and insertion of patient specific implants is not only an uprising field of research but is finding its way into clinical routines. Virtual surgical planning and computer-aided design and manufacturing have revolutionized work flows and therapies in dentistry and maxillofacial surgery. 3D and 4D printing of polymers has become popular in recent years. Printed absorbable plates for osteosynthesis of fractures or treatment of craniosynostosis are interesting new developments. Various 3D printing strategies have been developed to enable bioprinting of different biopolymers and hydrogels. Bioprinting offers new opportunities for bone and soft tissue regeneration.

This Special Issue welcomes in vitro, animal, pre-clinical studies and clinical studies on computer assisted surgery, computer-aided design (CAD) and manufacturing (CAM) and 3D-printing for dental and maxillofacial purposes. Moreover, studies on biomaterials applied in the oral and maxillofacial field are of interest.

Prof. Dr. Majeed Rana
Dr. Lara K. F. Schorn
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biopolymers
  • hydrogels
  • bioprinting
  • 3D and 4D printing
  • computer-aided design (CAD)
  • computer-aided manufacturing (CAM)

Published Papers (2 papers)

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Research

14 pages, 2948 KiB  
Article
Melatonin Mitigates iNOS-Related Effects of HEMA and Camphorquinone in Human Dental Pulp Cells: Relevance for Postoperative Sensitivity Mechanism in Type 2 Diabetes
by Jugoslav Ilić, Aleksandra Milosavljević, Miloš Lazarević, Maja Milošević Marković, Jelena Milašin, Milan Vučetić, Akhilanand Chaurasia, Vesna Miletić and Jelena Roganović
Int. J. Mol. Sci. 2023, 24(3), 2562; https://doi.org/10.3390/ijms24032562 - 29 Jan 2023
Cited by 1 | Viewed by 1598
Abstract
High elution and diffusion of 2-hydroxylethyl methacrylate (HEMA) and camphorquinone (CQ) through dentinal tubules may induce pulp injury and postoperative sensitivity. We aimed to investigate the melatonin protective effect in HEMA- and CQ-treated human dental pulp cells (hDPCs) as well as its relevance [...] Read more.
High elution and diffusion of 2-hydroxylethyl methacrylate (HEMA) and camphorquinone (CQ) through dentinal tubules may induce pulp injury and postoperative sensitivity. We aimed to investigate the melatonin protective effect in HEMA- and CQ-treated human dental pulp cells (hDPCs) as well as its relevance in a mechanism for postoperative sensitivity in diabetic patients. hDPCs were exposed to HEMA (5 mM) and/or CQ (1 mM) in the absence and presence of melatonin (MEL) (0.1 mM and 1 mM). Heme oxygenase-1 (HMOX1), NADPH oxidase-4 (NOX4), BCL-2-associated X-protein (BAX), B-cell lymphoma-2 (BCL-2) and caspase-3 (CASP3) gene expression levels, and superoxide dismutase (SOD) activity were measured in hDPCs while inducible nitric oxide synthase (iNOS) and melatonin protein expression were measured in human dental pulp as well, by RT-PCR, by ELISA, and spectrophotometrically. Bioinformatic analyses were performed by using the ShinyGO (v.0.75) application. Type 2 diabetic patients showed a higher incidence of postoperative sensitivity and lower melatonin and higher iNOS content in dental pulp tissue compared with non-diabetic patients. Melatonin, when co-added in hDPC culture, reverses HEMA and CQ cytotoxic effects via anti-apoptotic and anti-inflammatory/antioxidant iNOS-related effects. Enrichment analyses showed that genes/proteins, altered by HEMA and CQ and normalized by melatonin, are the most prominently overrepresented in type 2 diabetes mellitus pathways and that they share subcellular localization in different oligomeric protein complexes consisting of anti- and pro-apoptotic regulators. This is the first evidence of the ability of melatonin to counteract iNOS-mediated inflammatory and stress effects in HEMA- and CQ-treated hDPCs, which could be of significance for the modulation of presently observed immediate postoperative sensitivity after composite restoration in type 2 diabetic patients. Full article
(This article belongs to the Special Issue Biomaterials for Dental Applications and Implants)
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15 pages, 6275 KiB  
Article
Molybdenum as a Potential Biocompatible and Resorbable Material for Osteosynthesis in Craniomaxillofacial Surgery—An In Vitro Study
by André Toschka, Georg Pöhle, Peter Quadbeck, Christoph V. Suschek, Alexander Strauß, Christian Redlich and Majeed Rana
Int. J. Mol. Sci. 2022, 23(24), 15710; https://doi.org/10.3390/ijms232415710 - 11 Dec 2022
Cited by 5 | Viewed by 1425
Abstract
Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they [...] Read more.
Titanium and stainless steel are commonly known as osteosynthesis materials with high strength and good biocompatibility. However, they have the big disadvantage that a second operation for hardware removal is necessary. Although resorbable systems made of polymers or magnesium are increasingly used, they show some severe adverse foreign body reactions or unsatisfying degradation behavior. Therefore, we started to investigate molybdenum as a potential new biodegradable material for osteosynthesis in craniomaxillofacial surgery. To characterize molybdenum as a biocompatible material, we performed in vitro assays in accordance with ISO Norm 10993-5. In four different experimental setups, we showed that pure molybdenum and molybdenum rhenium alloys do not lead to cytotoxicity in human and mouse fibroblasts. We also examined the degradation behavior of molybdenum by carrying out long-term immersion tests (up to 6 months) with molybdenum sheet metal. We showed that molybdenum has sufficient mechanical stability over at least 6 months for implants on the one hand and is subject to very uniform degradation on the other. The results of our experiments are very promising for the development of new resorbable osteosynthesis materials for craniomaxillofacial surgery based on molybdenum. Full article
(This article belongs to the Special Issue Biomaterials for Dental Applications and Implants)
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