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Novel Insights into Cellular and Molecular Mechanisms of Autoimmune Disease
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Novel Insights into Cellular and Molecular Mechanisms of Autoimmune Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3567

Special Issue Editors

Dr. Kassem Sharif

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Guest Editor
Department of Gastroenterology, Chaim Sheba Medical Center, Affiliated to Tel Aviv University, Tel Aviv, Israel
Interests: gastroenterology; inflammatory bowel disease; celiac disease
Special Issues, Collections and Topics in MDPI journals
Dr. Adi Lahat

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Guest Editor
Department of Gastroenterology, Chaim Sheba Medical Center, Affiliated to Tel Aviv University, Tel Aviv, Israel
Interests: gastroenterology; inflammatory bowel disease; diverticular disease; patient health; endoscopy; CRC screening
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The cellular and molecular mechanisms underlying autoimmune diseases are complex and multifactorial, involving the dysregulation of various immune cell populations, genetic susceptibility, and environmental factors. Understanding these mechanisms is crucial for developing effective treatments and therapies for autoimmune diseases.

Recent technological and scientific advancements have led to novel approaches in studies of the cellular and molecular mechanisms of autoimmune diseases such as single-cell transcriptomics, which enables the analysis of gene expression in individual cells. High-throughput screening technologies have also been employed to identify novel targets for drug development. These techniques enable the rapid screening of large libraries of compounds to identify molecules that can modulate specific cellular pathways involved in autoimmune diseases.

The purpose of this Special Issue is to increase the depth of understanding pertinent to cellular and molecular mechanisms of autoimmune diseases, as well as to identify targets of novel therapy and possible side effects of immune blockage used in the treatment of autoimmune diseases.

Dr. Kassem Sharif
Dr. Adi Lahat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmune diseases
  • immunotherapy
  • molecular pathway
  • innate immunity
  • gastroenterology
  • allergy

Published Papers (2 papers)

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Review

12 pages, 637 KiB  
Review
An Emerging Role for Anti-DNA Antibodies in Systemic Lupus Erythematosus
by Tetsuo Kubota
Int. J. Mol. Sci. 2023, 24(22), 16499; https://doi.org/10.3390/ijms242216499 - 19 Nov 2023
Viewed by 1277
Abstract
Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but their pathogenetic role is not fully understood. Accumulating evidence suggests that some anti-DNA antibodies enter different types of live cells and affect the pathophysiology of SLE by stimulating or impairing these [...] Read more.
Anti-DNA antibodies are hallmark autoantibodies produced in systemic lupus erythematosus (SLE), but their pathogenetic role is not fully understood. Accumulating evidence suggests that some anti-DNA antibodies enter different types of live cells and affect the pathophysiology of SLE by stimulating or impairing these cells. Circulating neutrophils in SLE are activated by a type I interferon or other stimuli and are primed to release neutrophil extracellular traps (NETs) on additional stimulation. Anti-DNA antibodies are also involved in this process and may induce NET release. Thereafter, they bind and protect extracellular DNA in the NETs from digestion by nucleases, resulting in increased NET immunogenicity. This review discusses the pathogenetic role of anti-DNA antibodies in SLE, mainly focusing on recent progress in the two research fields concerning antibody penetration into live cells and NETosis. Full article
(This article belongs to the Special Issue Novel Insights into Cellular and Molecular Mechanisms of Autoimmune Disease)
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17 pages, 1249 KiB  
Review
Unraveling the Immunopathological Landscape of Celiac Disease: A Comprehensive Review
by Yonatan Shneor Patt, Adi Lahat, Paula David, Chen Patt, Rowand Eyade and Kassem Sharif
Int. J. Mol. Sci. 2023, 24(20), 15482; https://doi.org/10.3390/ijms242015482 - 23 Oct 2023
Viewed by 1839
Abstract
Celiac disease (CD) presents a complex interplay of both innate and adaptive immune responses that drive a variety of pathological manifestations. Recent studies highlight the role of immune-mediated pathogenesis, pinpointing the involvement of antibodies against tissue transglutaminases (TG2, TG3, TG6), specific HLA molecules [...] Read more.
Celiac disease (CD) presents a complex interplay of both innate and adaptive immune responses that drive a variety of pathological manifestations. Recent studies highlight the role of immune-mediated pathogenesis, pinpointing the involvement of antibodies against tissue transglutaminases (TG2, TG3, TG6), specific HLA molecules (DQ2/8), and the regulatory role of interleukin-15, among other cellular and molecular pathways. These aspects illuminate the systemic nature of CD, reflecting its wide-reaching impact that extends beyond gastrointestinal symptoms to affect other physiological systems and giving rise to a range of pathological landscapes, including refractory CD (RCD) and, in severe cases, enteropathy-associated T cell lymphoma. The existing primary therapeutic strategy, a gluten-free diet (GFD), poses significant challenges, such as low adherence rates, necessitating alternative treatments. Emerging therapies target various stages of the disease pathology, from preventing immunogenic gluten peptide absorption to enhancing intestinal epithelial integrity and modulating the immune response, heralding potential breakthroughs in CD management. As the understanding of CD deepens, novel therapeutic avenues are emerging, paving the way for more effective and sophisticated treatment strategies with the aim of enhancing the quality of life of CD patients. This review aims to delineate the immunopathology of CD and exploring its implications on other systems, its complications and the development of novel treatments. Full article
(This article belongs to the Special Issue Novel Insights into Cellular and Molecular Mechanisms of Autoimmune Disease)
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