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Innovative Approaches to Understand, Prevent and Eradicate Biofilms and Related Infections—a New Look from Natural Compounds to Nanotechnology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 2865

Special Issue Editor

Dr. Emil Paluch

E-Mail Website
Guest Editor
Department of Microbiology, Faculty of Medicine, Wrocław Medical University, T. Chałubińskiego, 4 50-376 Wroclaw, Poland
Interests: quorum quenching; quorum sensing; molecular mechanism of action; Candida; CLSM; surfactants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biofilm has remained a major challenge for medicine for many years. Increasingly, multi-drug resistant strains are being reported for which antibiotics no longer work, indicating a clear evolution of microbes. Therefore, it is crucial to develop innovative approaches to understand, prevent, and eradicate biofilms and their associated infections, as they represent a significant public health challenge. Natural compounds and nanotechnology have the potential to successfully overcome the limitations of conventional antimicrobials and offer effective treatments for microbial infections. Perhaps a broad look at the current problems will reveal the potential of natural compounds to potentate the activity of conventional antibiotics, achieve adhesion inhibition, disrupt mature biofilms and ensure their eradication, and equip us with a solution. Likewise, nanotechnology provides novel opportunities to combat biofilm-related infections.

The Special Issue will focus on innovative approaches to understand, prevent, and eliminate biofilms using natural compounds and nanotechnology. We invite you to participate in this issue with novel contributions, as it is a great opportunity to aid in the fight against biofilm.

Dr. Emil Paluch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • natural compounds
  • nanotechnology
  • antibiotic resistance
  • mechanism of compound
  • bacteria
  • fungi
  • public health

Published Papers (2 papers)

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Research

16 pages, 2954 KiB  
Article
Mechanism of Action and Efficiency of Ag3PO4-Based Photocatalysts for the Control of Hazardous Gram-Positive Pathogens
by Emil Paluch, Alicja Seniuk, Gustav Plesh, Jarosław Widelski, Damian Szymański, Rafał J. Wiglusz, Martin Motola and Ewa Dworniczek
Int. J. Mol. Sci. 2023, 24(17), 13553; https://doi.org/10.3390/ijms241713553 - 31 Aug 2023
Cited by 2 | Viewed by 1087
Abstract
Silver phosphate and its composites have been attracting extensive interest as photocatalysts potentially effective against pathogenic microorganisms. The purpose of the present study was to investigate the mechanism of bactericidal action on cells of opportunistic pathogens. The Ag3PO4/P25 (AGP/P25) [...] Read more.
Silver phosphate and its composites have been attracting extensive interest as photocatalysts potentially effective against pathogenic microorganisms. The purpose of the present study was to investigate the mechanism of bactericidal action on cells of opportunistic pathogens. The Ag3PO4/P25 (AGP/P25) and Ag3PO4/HA (HA/AGP) powders were prepared via a co-precipitation method. Thereafter, their antimicrobial properties against Enterococcus faecalis, Staphylococcus epidermidis, and Staphylococcus aureus (clinical and reference strains) were analyzed in the dark and after exposure to visible light (VIS). The mechanism leading to cell death was investigated by the leakage of metabolites and potassium ions, oxidative stress, and ROS production. Morphological changes of the bacterial cells were visualized by transmission electron microscopy (TEM) and scanning transmission electron microscopy with energy-dispersive X-ray spectroscopy (SEM EDS) analysis. It has been shown that Ag3PO4-based composites are highly effective agents that can eradicate 100% of bacterial populations during the 60 min photocatalytic inactivation. Their action is mainly due to the production of hydroxyl radicals and photogenerated holes which lead to oxidative stress in cells. The strong affinity to the bacterial cell wall, as well as the well-known biocidal properties of silver itself, increase undoubtedly the antimicrobial potential of the Ag3PO4-based composites. Full article
(This article belongs to the Special Issue Innovative Approaches to Understand, Prevent and Eradicate Biofilms and Related Infections—a New Look from Natural Compounds to Nanotechnology)
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24 pages, 7349 KiB  
Article
Photocatalytic and Photothermal Antimicrobial Mussel-Inspired Nanocomposites for Biomedical Applications
by Luis F. Soto-Garcia, Ingrid D. Guerrero-Rodriguez, Luu Hoang, Samantha Lauren Laboy-Segarra, Ngan T. K. Phan, Enrique Villafuerte, Juhyun Lee and Kytai T. Nguyen
Int. J. Mol. Sci. 2023, 24(17), 13272; https://doi.org/10.3390/ijms241713272 - 26 Aug 2023
Cited by 1 | Viewed by 1284
Abstract
Bacterial infection has traditionally been treated with antibiotics, but their overuse is leading to the development of antibiotic resistance. This may be mitigated by alternative approaches to prevent or treat bacterial infections without utilization of antibiotics. Among the alternatives is the use of [...] Read more.
Bacterial infection has traditionally been treated with antibiotics, but their overuse is leading to the development of antibiotic resistance. This may be mitigated by alternative approaches to prevent or treat bacterial infections without utilization of antibiotics. Among the alternatives is the use of photo-responsive antimicrobial nanoparticles and/or nanocomposites, which present unique properties activated by light. In this study, we explored the combined use of titanium oxide and polydopamine to create nanoparticles with photocatalytic and photothermal antibacterial properties triggered by visible or near-infrared light. Furthermore, as a proof-of-concept, these photo-responsive nanoparticles were combined with mussel-inspired catechol-modified hyaluronic acid hydrogels to form novel light-driven antibacterial nanocomposites. The materials were challenged with models of Gram-negative and Gram-positive bacteria. For visible light, the average percentage killed (PK) was 94.6 for E. coli and 92.3 for S. aureus. For near-infrared light, PK for E. coli reported 52.8 and 99.2 for S. aureus. These results confirm the exciting potential of these nanocomposites to prevent the development of antibiotic resistance and also to open the door for further studies to optimize their composition in order to increase their bactericidal efficacy for biomedical applications. Full article
(This article belongs to the Special Issue Innovative Approaches to Understand, Prevent and Eradicate Biofilms and Related Infections—a New Look from Natural Compounds to Nanotechnology)
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