Cellular and Molecular Mechanisms of HIV-1-Associated Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 August 2024 | Viewed by 213
Special Issue Editors
Interests: HIV-1 therapy; innate immunity; HIV-associated cardiovascular diseases
Interests: HIV pathogenesis and cure; HIV/TB coinfection; aging mucosal immunity and inflammation of aging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the era of combination antiretroviral therapy (cART), individuals living with HIV (PLWH) face a twofold higher likelihood of developing cardiovascular disease (CVD) compared to those without HIV. The global prevalence of CVD linked to HIV has tripled over the last two decades. While HIV-related CVD used to primarily manifest as conditions such as dilated cardiomyopathy, pericardial disease, and pulmonary hypertension, the widespread use of cART has shifted the pattern towards atherosclerosis-related issues, including heart attack, stroke, and heart failure. This increased CVD risk in PLWH is attributed to chronic HIV-driven inflammation. Although clinical research is growing, experimental studies on this subject are scarce.
An improved understanding of the mechanisms driving the development of CVD in PLWH could lead to better strategies for its prevention. For instance, this might involve targeting specific molecules within pathways that worsen the disease and developing new immunomodulatory therapies. The main goal of this Special Issue is to present a comprehensive overview of the current understanding of the origins of CVD linked to HIV-1. As a result, we encourage the submission of original research and review papers that focus on a range of subjects, including, though not confined to, the following topics:
- Identification of novel biomarkers of HIV-1-associated CVD;
- Changes in immune cell functions and signaling pathways associated with CVD in HIV or SIV infection;
- Experimental model studies of HIV-associated CVD;
- Effects of cART, diet, microbiota, etc., on atherosclerosis during HIV/SIV infection;
- Clinical studies on cardiovascular disease and HIV.
Since IJMS is a journal of molecular science, pure clinical studies will not be suitable for our journal. But, clinical submissions which feature biomolecular experiments are welcomed.
Prof. Dr. Xuebin Qin
Dr. Namita Rout
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- HIV
- SIV
- nonhuman primates
- atherosclerosis
- myocardial infarction (MI)
- stroke
- heart failure
- immune activation
- macrophage/monocyte activation
- molecular and cellular mechanisms
- chronic infection
- animal models
- clinical studies
