Recent Advances in the Regulation and Signaling of Small GTPases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 1166
Special Issue Editor
Interests: intracellular signal transduction; small GTPases; diabetes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The family of signal-transducing small GTPases serves as a molecular switch for intracellular signal transduction in eukaryotic cells. It has been implicated in a diverse array of cell functions, such as gene expression, cytoskeletal rearrangements, the intracellular transport of vesicles, and macromolecular transport across the nuclear envelope. In humans, defects in small-GTPase-mediated signaling are intimately involved in various diseases, including cancer. In contrast to heterotrimeric G proteins, another family of signal transducing GTPases, small GTPases, acts as a monomer (a single polypeptide) attached to cell and intracellular membranes through post-translational lipid modifications. Virtually all small GTPases exist in either a GDP-bound or GTP-bound conformation, interacting with specific regulatory and target proteins in a manner dependent on the bound GDP or GTP. In many cases, upstream signals such as receptor-mediated signals stimulate the formation of the GTP-bound conformation, which, in turn, activates downstream targets.
This Special Issue on “Recent Advances in the Regulation and Signaling of Small GTPases” aims to provide new insights into the physiological functions and regulatory mechanisms of any kind of signal transducing small GTPases in all types of cells, including bacterial, yeast, and mammalian cells. Authors are invited to submit original research and review articles related to these subjects.
Prof. Dr. Takaya Satoh
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- cell growth
- cell motility
- guanine nucleotide exchange
- protein–protein interaction
- signal transduction
- vesicular transport
