Special Issue "Advances in Endoplasmic Reticulum Stress and Apoptosis"
Deadline for manuscript submissions: 31 October 2023 | Viewed by 211
Interests: endoplasmic reticulum stress; autophagy; cellular survival; systems biology
The endoplasmic reticulum (ER) acts as an essential integrator of external and internal stimuli in order to preserve cellular homeostasis. This process is tightly regulated by a complex network of signalling pathways called the unfolded protein response (UPR). The accumulation of incorrectly folded proteins or metabolic imbalance in ER lumen leads to ER stress, which primarily triggers the adaptive functions of UPR to avoid cell damage. If readjustment efforts fail, unresolved ER stress can lead to cell death mechanisms including apoptosis and other newly described cell killing processes. Autophagy was also claimed to be initiated by ER stress as a protective pathway from cell damage. The role of ER stress is becoming increasingly important in a wide range of human diseases; it is always appropriate to update its effects as thoroughly as possible.
The goal of this Special Issue is to showcase both the development and the current challenges/benefits of studying ER stress and the related signalling pathways. This Special Issue will include both review articles and original research papers to address the diversity of pathways in cell death initiated by ER imbalance and their integration in various diseases.
Dr. Orsolya Kapuy
Dr. Beáta Lizák
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- ER stress
- apoptosis initiated by ER stress
- cellular survival
- redox homeostasis of ER
- autophagy initiated by ER stress
- cell death pathways initiated by ER stress