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Historic Genomics: An Emergent Discipline

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 370

Special Issue Editor

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Guest Editor
Department of Immunology, Universidad Complutense de Madrid, 28012 Madrid, Spain
Interests: HLA; MHC-G; immunology; population genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The present issue contains papers that show how the diversity of different genetic markers across the world populations may be useful to obtain inferences about their historical–prehistorical interactions. History has been a speculative topic and many of its basic supports are only premises that have not been confronted with objectivity because of a lack of appropriate data. The widespread use of gene amplification and other more advanced technologies developed by genomics allow us to easily study full genomes, diseased genes, and gene diversity within populations. This variability is useful to confront the historic premises or “dogma” with objective genetic data. Gene variability is not yet studied in humans on a large scale and the following decades will be needed to study both the nondiseased-linked and the diseased-linked genes.

Epidemiological genomics will be a fully developed science when a map of the genes linked to diseases will be on its way of being constructed. This will be the basis of a predictive medicine that will have a remarkable social and economic importance in the present century. Therefore, historic genomics is slowly being developed by comparing genetic variability between populations with the available historical postulates.

The HLA community has been unable to show anthropologists how useful the polymorphic human genetic system could be to study population genetics and historic genomics. A few HLA alleles, mtDNA, and Y-chromosome variants are all linked to diseases that may have been common in the past or in certain populations and are also useful for the historic genomics study.

Furthermore, polymorphic genes are currently in use in population genetics: full genome studies, SNPs, and STRs. However, low polymorphic gene markers may be useless for distinguishing populations since “noise“ is too high, and thus, the distinguishability of population is reduced. Even now, a geographic discrimination is a good sign of a good marker. Both HLA and Y-chromosome markers are good examples of markers with clear geographic gradients.

Prof. Dr. Antonio Arnaiz-Villena
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • history
  • genomics
  • mtDNA
  • Y chromosome
  • HLA
  • SNPs
  • STRs
  • genetic markers
  • full genome

Published Papers

This special issue is now open for submission.
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