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Special Issue "Structure and Function of Macromolecular Interactions"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 2274

Special Issue Editor

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
Interests: structural biology; 3D image reconstruction; microscopy; vaccine design; virus structures; molecular medicine; genomics; proteomics; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The state-of-art biochemical/biophysical methods used in structural studies are vast, ranging from hydrodynamic to scattering techniques, and have played a fundamental role in our understanding of viral infection in recent years. Macromolecular interactions have provided insights into the complex assembles, involving quaternary dynamics, nucleotide packaging, and heterologous–molecule interactions. This Special Issue, "Structure and Function of Macromolecular Interactions", intends to gather the recently unveiled interactions that allow the elucidation of mechanistic pathways that govern biological processes at the atomic and molecular levels. The method undertaken for any particular study contributes crucial information concerning the representative visualized discrete dynamic states. With joint efforts in the field, we will publish works that structurally characterize chosen macromolecules to formulate common platforms to develop targets for therapeutic intervention and improved vector designs for gene delivery.

Prof. Dr. R. Holland Cheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • macromolecular assembly
  • conformational proteomics
  • molecular dynamics
  • structure determination
  • membrane proteins
  • Bayesian structural time series/modeling

Published Papers (1 paper)

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21 pages, 1441 KiB  
The Knowns and Unknowns in Protein–Metabolite Interactions
Int. J. Mol. Sci. 2023, 24(4), 4155; https://doi.org/10.3390/ijms24044155 - 19 Feb 2023
Cited by 2 | Viewed by 2037
Increasing attention has been focused on the study of protein–metabolite interactions (PMI), which play a key role in regulating protein functions and directing an orchestra of cellular processes. The investigation of PMIs is complicated by the fact that many such interactions are extremely [...] Read more.
Increasing attention has been focused on the study of protein–metabolite interactions (PMI), which play a key role in regulating protein functions and directing an orchestra of cellular processes. The investigation of PMIs is complicated by the fact that many such interactions are extremely short-lived, which requires very high resolution in order to detect them. As in the case of protein–protein interactions, protein–metabolite interactions are still not clearly defined. Existing assays for detecting protein–metabolite interactions have an additional limitation in the form of a limited capacity to identify interacting metabolites. Thus, although recent advances in mass spectrometry allow the routine identification and quantification of thousands of proteins and metabolites today, they still need to be improved to provide a complete inventory of biological molecules, as well as all interactions between them. Multiomic studies aimed at deciphering the implementation of genetic information often end with the analysis of changes in metabolic pathways, as they constitute one of the most informative phenotypic layers. In this approach, the quantity and quality of knowledge about PMIs become vital to establishing the full scope of crosstalk between the proteome and the metabolome in a biological object of interest. In this review, we analyze the current state of investigation into the detection and annotation of protein–metabolite interactions, describe the recent progress in developing associated research methods, and attempt to deconstruct the very term “interaction” to advance the field of interactomics further. Full article
(This article belongs to the Special Issue Structure and Function of Macromolecular Interactions)
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