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Special Issue "Nano-Bio Interaction"

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College of Natural and Applied Sciences, Missouri State University, Springfield, MO, USA
Interests: yeast; cancer cells; nanoparticles; nanomaterials; transcriptomics; proteomics; metabolomics; nano–bio interaction; nanotoxicology

Special Issue Information

Dear Colleagues,

It is true that nanomaterials that already exist or are on the horizon are expanding tremendously in the name of industrial development and human health. One of the things that should accompany this enormous expansion is a thorough investigation of the mechanisms by which these nanomaterials interact with macromolecules at the cellular/tissue/organismal level, in addition to the resulting adverse cellular effects, if any. Multi-omics research, including transcriptomics, proteomics, and metabolomics, is long overdue as a research pillar or standard for answering these questions. In addition to these methodologies, it is safe to say that the study of nano-cellular macromolecular interactions at the individual level is a new field of research that is slowly gaining prominence. Therefore, this Special Issue is focused on collecting original research on or reviews of recent advances in the cellular and molecular mechanisms in nanotoxicology.

Prof. Dr. Kyoungtae Kim
Guest Editor

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Keywords

nano–bio interaction
nanotoxicology
nanomedicine
environmental impact of nanomaterials
assessing nanomaterials to human health
mechanism(s) of toxicity
dispersion of nanomaterials and the impacts
transcriptomics
proteomics
metabolomics
epigenetics
genomics
biochemical characterization of nano–macromolecule interaction

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Research

13 pages, 2938 KiB

Open AccessArticle

The Impact of Cadmium Selenide Zinc Sulfide Quantum Dots on the Proteomic Profile of Saccharomyces cerevisiae

and

Int. J. Mol. Sci. 2023, 24(22), 16332; https://doi.org/10.3390/ijms242216332 - 15 Nov 2023

Viewed by 280

Abstract

Quantum dots (QDs) have been highly sought after in the past few decades for their potential to be used in many biomedical applications. However, QDs’ cytotoxicity is still a major concern that limits the incorporation of QDs into cutting-edge technologies. Thus, it is important to study and understand the mechanism by which QDs exert their toxicity. Although many studies have explored the cytotoxicity of quantum dots through the transcriptomic level and reactive species generation, the impact of quantum dots on the expression of cellular protein remains unclear. Using Saccharomyces cerevisiae as a model organism, we studied the effect of cadmium selenide zinc sulfide quantum dots (CdSe/ZnS QDs) on the proteomic profile of budding yeast cells. We found a total of 280 differentially expressed proteins after 6 h of CdSe/ZnS QDs treatment. Among these, 187 proteins were upregulated, and 93 proteins were downregulated. The majority of upregulated proteins were found to be associated with transcription/RNA processing, intracellular trafficking, and ribosome biogenesis. On the other hand, many of the downregulated proteins are associated with cellular metabolic pathways and mitochondrial components. Through this study, the cytotoxicity of CdSe/ZnS QDs on the proteomic level was revealed, providing a more well-rounded knowledge of QDs’ toxicity. Full article

(This article belongs to the Special Issue Nano-Bio Interaction)

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17 pages, 3053 KiB

Open AccessArticle

Interactions between Quantum Dots and G-Actin

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Int. J. Mol. Sci. 2023, 24(19), 14760; https://doi.org/10.3390/ijms241914760 - 29 Sep 2023

Cited by 1 | Viewed by 409

Abstract

Quantum dots (QDs) are a type of nanoparticle with excellent optical properties, suitable for many optical-based biomedical applications. However, the potential of quantum dots to be used in clinical settings is limited by their toxicity. As such, much effort has been invested to examine the mechanism of QDs’ toxicity. Yet, the current literature mainly focuses on ROS- and apoptosis-mediated cell death induced by QDs, which overlooks other aspects of QDs’ toxicity. Thus, our study aimed to provide another way by which QDs negatively impact cellular processes by investigating the possibility of protein structure and function modification upon direct interaction. Through shotgun proteomics, we identified a number of QD-binding proteins, which are functionally associated with essential cellular processes and components, such as transcription, translation, vesicular trafficking, and the actin cytoskeleton. Among these proteins, we chose to closely examine the interaction between quantum dots and actin, as actin is one of the most abundant proteins in cells and plays crucial roles in cellular processes and structural maintenance. We found that CdSe/ZnS QDs spontaneously bind to G-actin in vitro, causing a static quenching of G-actin’s intrinsic fluorescence. Furthermore, we found that this interaction favors the formation of a QD–actin complex with a binding ratio of 1:2.5. Finally, we also found that CdSe/ZnS QDs alter the secondary structure of G-actin, which may affect G-actin’s function and properties. Overall, our study provides an in-depth mechanistic examination of the impact of CdSe/ZnS QDs on G-actin, proposing that direct interaction is another aspect of QDs’ toxicity. Full article

(This article belongs to the Special Issue Nano-Bio Interaction)

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