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Research Advances in Neurodegeneration and Neuropathy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 1475

Special Issue Editor


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Guest Editor
Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan
Interests: neuropharmacology; stem cell; neurodegeneration; itching; neuroprotection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past few years, some medications have been shown to have the effect of neuroprotection on neurodegenerative diseases through the regulation of synaptic plasticity, mitochondria functions, orexin systems, autophagocytosis, neuroinflammation, intestinal microbiota, etc. Furthermore, the application of the human gene project, the development of artificial intelligence, and new automatic behavior monitors rapidly expanded the vision of clinical and basic molecular research of neurodegenerative diseases and neuropathy.

For an upcoming Issue in the International Journal of Molecular Sciences, we encourage researchers to submit original research articles on neurobiology, as well as review articles.

Topics for this Special Issue include, but are not limited to:

  • Molecular mechanisms on neuroprotection such as: synaptic proteins, DNA repair, apoptosis, autophagy, mitochondria, gene expression, signaling pathway, neuroinflammation, neuron regeneration, vascular remodeling, and Tau protein
  • Mechanisms of neurohormonal, neurotransmitter, and neuropeptides 
  • High-throughput technologies: genomics, epigenomics, proteomics, metabolomics, microarray, next-generation sequencing, and other omics technologies
  • Genomic and proteomic databases and applications
  • Automatic behavior monitors in the neurodegenerative or neuropathy animal model study

Dr. Yi-Hung Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mechanism
  • neurodegenerative disease
  • neuropathy

Published Papers (1 paper)

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Research

17 pages, 6541 KiB  
Article
Protective Effect of Electroacupuncture on Chemotherapy-Induced Salivary Gland Hypofunction in a Mouse Model
by Thanh-Hien Vu Nguyen, Kuo-Chou Chiu, Yin-Hwa Shih, Chung-Ji Liu, Tran Van Bao Quach, Shih-Min Hsia, Yi-Hung Chen and Tzong-Ming Shieh
Int. J. Mol. Sci. 2023, 24(14), 11654; https://doi.org/10.3390/ijms241411654 - 19 Jul 2023
Cited by 1 | Viewed by 1193
Abstract
Radiotherapy and chemotherapy can impair salivary gland (SG) function, which causes xerostomia and exacerbate other side effects of chemotherapy and oral infection, reducing patients’ quality of life. This animal study aimed to assess the efficacy of electroacupuncture (EA) as a means of preventing [...] Read more.
Radiotherapy and chemotherapy can impair salivary gland (SG) function, which causes xerostomia and exacerbate other side effects of chemotherapy and oral infection, reducing patients’ quality of life. This animal study aimed to assess the efficacy of electroacupuncture (EA) as a means of preventing xerostomia induced by 5−fluorouracil (5−FU). A xerostomia mouse model was induced via four tail vein injections of 5−FU (80 mg/kg/dose). EA was performed at LI4 and LI11 for 7 days. The pilocarpine-stimulated salivary flow rate (SFR) and salivary glands weight (SGW) were recorded. Salivary immunoglobulin A (SIgA) and lysozyme were determined via enzyme-linked immunosorbent assay (ELISA). SG was collected for hematoxylin and eosin staining to measure acini number and acinar cell size. Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and aquaporin 5 (AQP5) mRNA expressions in SG were quantified via RT-qPCR. 5−FU caused significant decreases in SFR, SGW, SIgA, lysozyme, AQP5 expression, and acini number, while TNF-α and IL-1β expressions and acinar cell size were significantly increased. EA treatment can prevent 5−FU damage to the salivary gland, while pilocarpine treatment can only elevate SFR and AQP5 expression. These findings provide significant evidence to support the use of EA as an alternative treatment for chemotherapy-induced salivary gland hypofunction and xerostomia. Full article
(This article belongs to the Special Issue Research Advances in Neurodegeneration and Neuropathy)
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