Structural Biology of Peptides and Proteins in Alzheimer's Disease and Related Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 2326
Special Issue Editors
Interests: protein structure and function; peptides; intermolecular interactions; molecular mechanism of protein functioning; intrinsically disordered protein (IDP); protein toxins; lipid membranes; proteolipid complexes; protein-RNA/DNA complexes; membrane receptors; pathogenic mutations; signal transduction; Alzheimer disease; oncology; structural biology; biophysics; NMR; X-ray; SAXS; molecular dynamics
Special Issue Information
Dear Colleagues,
Within a century of its discovery, Alzheimer’s disease (AD) has become a major threat to the health of the mature population, taking its lethal toll alongside cardiovascular impairments and imposing a heavy burden on families, medical care and social systems. AD positively correlates and its putative mechanisms interfere with a number of neurodegenerative, cardiovascular and metabolic disorders. Current AD treatments mostly focus on alleviating pathological manifestations and behavioral symptoms rather than affecting the underlying processes and the few available exceptions yielded only a limited clinical success. The disease development is determined by complex interactions between diverse factors: biochemistry, general health, environmental, lifestyle and behavioral conditions. AD molecular mechanisms are intriguingly complicated, involving a range of interrelated key players: peptides and proteins (APP, its cleavage products, phosphorylated tau-protein), lipids (cholesterol, sphingolipids, gangliosides), multiple signaling pathways, free radicals (ROS, lipid peroxides) and metal ions (Zn, Cu). This Issue focuses on the roles and interrelations of constitutive proteins and peptides and their potential implications for novel AD treatment strategies. Recent insights into structure and function of structured and intrinsically disordered peptides offer promising opportunities for designing synthetic peptides capable of arresting AD development and progression. Their effectiveness can be augmented by concerted effects on other key players, including targeted lipid, antioxidant and metal ion supplementation.
Dr. Eduard V. Bocharov
Dr. Konstantin Pavlov
Guest Editors
Manuscript Submission Information
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Keywords
- Alzheimer’s disease
- Abeta peptides
- amyloid precursor protein
- tau protein
- structure
- function
- signaling pathway
- drug development
