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The Effects of Natural Compounds in Cell Differentiation and Signaling...
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The Effects of Natural Compounds in Cell Differentiation and Signaling Pathways 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 August 2023) | Viewed by 3489

Special Issue Editor

Prof. Dr. Davide Barreca

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy
Interests: plant biochemistry; isolation and identification of polyphenols; evaluation of biological potentials of polyphenols on isolate cells in culture; identification of molecular mechanisms of antioxidants action
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemicals are natural compounds produced by many kinds of plants, and their function is generally to help them thrive or thwart predators or pathogens. It is reported that there are several beneficial effects of phytochemicals on human health such as anti-cancer, anti-immune-response, anti-bacterial, and antioxidant effects. Over the last ten years, phytochemicals have been widely investigated to develop effective medicines for the treatment of various diseases because of their high efficacy and minimal side effects.

In this specific issue, we are gathering manuscripts (reviews and articles) about the regulation of cellular processes and signaling pathways by novel phytochemicals that could be applied to the development of functional foods (nutraceuticals), functional cosmetics (cosmeceuticals), and even medicines.

Prof. Dr. Davide Barreca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive
  • nutraceuticals
  • cosmeceuticals
  • functional foods
  • functional cosmetics
  • medicinal plants
  • signaling pathway
  • inhibitor
  • activator
  • cell differentiation

Published Papers (2 papers)

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Research

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18 pages, 3052 KiB  
Article
A Novel Resveratrol-Induced Pathway Increases Neuron-Derived Cell Resilience against Oxidative Stress
by Patrizio Cracco, Emiliano Montalesi, Martina Parente, Manuela Cipolletti, Giovanna Iucci, Chiara Battocchio, Iole Venditti, Marco Fiocchetti and Maria Marino
Int. J. Mol. Sci. 2023, 24(6), 5903; https://doi.org/10.3390/ijms24065903 - 21 Mar 2023
Viewed by 1366
Abstract
A promising therapeutic strategy to delay and/or prevent the onset of neurodegenerative diseases (NDs) could be to restore neuroprotective pathways physiologically triggered by neurons against stress injury. Recently, we identified the accumulation of neuroglobin (NGB) in neuronal cells, induced by the 17β-estradiol (E2)/estrogen [...] Read more.
A promising therapeutic strategy to delay and/or prevent the onset of neurodegenerative diseases (NDs) could be to restore neuroprotective pathways physiologically triggered by neurons against stress injury. Recently, we identified the accumulation of neuroglobin (NGB) in neuronal cells, induced by the 17β-estradiol (E2)/estrogen receptor β (ERβ) axis, as a protective response that increases mitochondria functionality and prevents the activation of apoptosis, increasing neuron resilience against oxidative stress. Here, we would verify if resveratrol (Res), an ERβ ligand, could reactivate NGB accumulation and its protective effects against oxidative stress in neuronal-derived cells (i.e., SH-SY5Y cells). Our results demonstrate that ERβ/NGB is a novel pathway triggered by low Res concentrations that lead to rapid and persistent NGB accumulation in the cytosol and in mitochondria, where the protein contributes to reducing the apoptotic death induced by hydrogen peroxide (H2O2). Intriguingly, Res conjugation with gold nanoparticles increases the stilbene efficacy in enhancing neuron resilience against oxidative stress. As a whole, ERβ/NGB axis regulation is a novel mechanism triggered by low concentration of Res to regulate, specifically, the neuronal cell resilience against oxidative stress reducing the triggering of the apoptotic cascade. Full article
(This article belongs to the Special Issue The Effects of Natural Compounds in Cell Differentiation and Signaling Pathways 2.0)
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Review

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20 pages, 1670 KiB  
Review
Catechins and Proanthocyanidins Involvement in Metabolic Syndrome
by Giuseppe Tancredi Patanè, Stefano Putaggio, Ester Tellone, Davide Barreca, Silvana Ficarra, Carlo Maffei, Antonella Calderaro and Giuseppina Laganà
Int. J. Mol. Sci. 2023, 24(11), 9228; https://doi.org/10.3390/ijms24119228 - 25 May 2023
Cited by 5 | Viewed by 1728
Abstract
Recent studies on natural antioxidant compounds have highlighted their potentiality against various pathological conditions. The present review aims to selectively evaluate the benefits of catechins and their polymeric structure on metabolic syndrome, a common disorder characterized by a cluster of three main risk [...] Read more.
Recent studies on natural antioxidant compounds have highlighted their potentiality against various pathological conditions. The present review aims to selectively evaluate the benefits of catechins and their polymeric structure on metabolic syndrome, a common disorder characterized by a cluster of three main risk factors: obesity, hypertension, and hyperglycemia. Patients with metabolic syndrome suffer chronic low inflammation state and oxidative stress both conditions effectively countered by flavanols and their polymers. The mechanism behind the activity of these molecules has been highlighted and correlated with the characteristic features present on their basic flavonoidic skelethon, as well as the efficient doses needed to perform their activity in both in vitro and in vivo studies. The amount of evidence provided in this review offers a starting point for flavanol dietary supplementation as a potential strategy to counteract several metabolic targets associated with metabolic syndrome and suggests a key role of albumin as flavanol-delivery system to the different target of action inside the organism. Full article
(This article belongs to the Special Issue The Effects of Natural Compounds in Cell Differentiation and Signaling Pathways 2.0)
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