Mitochondrial Dysfunction in Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 1912
Special Issue Editor
Interests: systemic lupus erythematosus; Sjögren’s syndrome; prolidase deficiency; free radical biology; experimental urolithiasis; curcumin and other curcuminoids; dietary supplements; microgravity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organ-specific autoimmune diseases (type 1 diabetes, thyroiditis, myasthenia gravis, primary biliary cirrhosis, multiple sclerosis, Goodpasture’s syndrome) or systemic autoimmunity (rheumatoid arthritis, progressive systemic sclerosis, systemic lupus erythematosus (SLE), Sjögren’s disease (SjD)) result from the abrogation of self-tolerance. Autoantibodies are characteristic of most of these diseases and are present several years before the diagnosis of SLE or SjD and serve as markers for future diseases. The precise involvement of cellular organelles concerning the etiology of inflammation in autoimmune diseases has not been fully explored. Mitochondrial dysfunction occurs in many of these diseases. Fatigue and other symptoms occur in most chronic diseases when an imbalance between biogenesis and mitophagy leads to progressive pathological conditions linked to mitochondrial dysfunction.
In this Special Issue of IJMS, we are looking for articles that delineate the molecular mechanisms mediating the pathological conditions of autoimmune diseases. This request would include articles that provide insights into molecular aspects of the initiation and progression of the disease by glandular, vascular endothelial cells, environmental triggers, cytokine activation of lymphocytes, the apoptosis of glandular cells, free radical-mediated oxidative damage, imbalance between mitochondrial biogenesis and mitophagy, mitochondrial structural changes, and mitochondrial dysfunction. We also welcome review papers in these areas and articles describing novel therapeutic targets and biomarkers.
Dr. Biji Theyilamannil Kurien
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmune diseases
- autoantibodies
- autophagy
- mitophagy
- mitochondrial hyperpolarization
- mitochondrial dysfunction
- oxidative phosphorylation
- oxidative damage
- fatigue
- chronic inflammation
