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Research in Membrane Transporters—Unveiling the Molecular Mechanisms and Practical Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 724

Special Issue Editors


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Guest Editor
Department of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wrocław, 50-328 Wroclaw, Poland
Interests: arsenic; antimony; molecular basis of metalloid toxicity and detoxification; yeast genetics and biology; membrane transporters; stress response; transport proteins; proteostasis

E-Mail Website1 Website2
Guest Editor
Department of Genetics and Cell Physiology, Faculty of Biological Sciences, University of Wrocław, 50-328 Wroclaw, Poland
Interests: arsenic; antimony; molecular basis of metalloid toxicity and detoxification; yeast genetics and biology; membrane transporters; stress response; transport proteins; proteostasis

Special Issue Information

Dear Colleagues,

The International Journal of Molecular Sciences (IJMS) is pleased to present a Special Issue dedicated to furthering our understanding of membrane transporters and their complex roles in biological systems. The purpose of this Special Issue is to provide a comprehensive forum for researchers and academics to discuss their most recent discoveries, methodology, and opinions in membrane transporters research.

Membrane transporters play crucial roles in cellular processes, including the uptake, efflux, and distribution of various molecules. Understanding their molecular mechanisms is essential to unravel the complexities of physiological and pathological processes, drug delivery, and therapeutic interventions.

This Special Issue welcomes contributions that bridge the gap between clinical observations and biomolecular experiments. Although pure clinical studies may not align with the journal's focus, submissions integrating clinical aspects with biomolecular experimentation will be highly valued. Researchers are encouraged to explore the diverse aspects of membrane transporter research, including structure–function relationships, regulation, modulation, transport kinetics, and implications for human health and disease.

Dr. Ewa Maciaszczyk-Dziubinska
Dr. Donata Wawrzycka
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • membrane transporters
  • transporter function
  • transporter regulation
  • transporter-mediated drug transport
  • transport-related diseases
  • biomolecular studies
  • pharmacokinetics
  • membrane proteostasis

Published Papers (1 paper)

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Review

30 pages, 1600 KiB  
Review
Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast
by Kacper Zbieralski, Jacek Staszewski, Julia Konczak, Natalia Lazarewicz, Malgorzata Nowicka-Kazmierczak, Donata Wawrzycka and Ewa Maciaszczyk-Dziubinska
Int. J. Mol. Sci. 2024, 25(8), 4450; https://doi.org/10.3390/ijms25084450 - 18 Apr 2024
Viewed by 375
Abstract
In the face of flourishing industrialization and global trade, heavy metal and metalloid contamination of the environment is a growing concern throughout the world. The widespread presence of highly toxic compounds of arsenic, antimony, and cadmium in nature poses a particular threat to [...] Read more.
In the face of flourishing industrialization and global trade, heavy metal and metalloid contamination of the environment is a growing concern throughout the world. The widespread presence of highly toxic compounds of arsenic, antimony, and cadmium in nature poses a particular threat to human health. Prolonged exposure to these toxins has been associated with severe human diseases, including cancer, diabetes, and neurodegenerative disorders. These toxins are known to induce analogous cellular stresses, such as DNA damage, disturbance of redox homeostasis, and proteotoxicity. To overcome these threats and improve or devise treatment methods, it is crucial to understand the mechanisms of cellular detoxification in metal and metalloid stress. Membrane proteins are key cellular components involved in the uptake, vacuolar/lysosomal sequestration, and efflux of these compounds; thus, deciphering the multilevel regulation of these proteins is of the utmost importance. In this review, we summarize data on the mechanisms of arsenic, antimony, and cadmium detoxification in the context of membrane proteome. We used yeast Saccharomyces cerevisiae as a eukaryotic model to elucidate the complex mechanisms of the production, regulation, and degradation of selected membrane transporters under metal(loid)-induced stress conditions. Additionally, we present data on orthologues membrane proteins involved in metal(loid)-associated diseases in humans. Full article
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