Immuno-Metabolism of Sepsis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1531
Special Issue Editors
Interests: sepsis; inflammation
Special Issue Information
Dear Colleagues,
Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The release of immune chemicals by innate immune cells plays a major role in mediating septic death. For example, HMGB1 can bind to multiple cell surface receptors, including RAGE and TLR4, to produce proinflammatory cytokines, chemokines, and adhesion molecules in various immune cells. Moreover, extracellular HMGB1 is capable of binding to various immune stimuli, such as lipopolysaccharide (LPS), DNA, and IgG, to produce synergistic effects on the inflammatory response. There are 31.5 million cases of sepsis globally, with an estimated death of 5.3 million people annually. The mortality rate of sepsis and septic shock varies from 25 to 30% and 40 to 50%.
Goal: Immunometabolism is an interdisciplinary field derived from classical immunology and metabolism with two main focuses: (1) the study of changes in cell immune metabolism that determine their fate, and (2) the effect of immune cells on tissue and systemic metabolism supporting the adaptation of individual changes. Metabolomics is a new area yet to be explored in sepsis.
Areas to be covered in this Special Issue may include, but are not limited to:
- Immune cell function and metabolism during sepsis;
- Lipidic metabolism in sepsis: free fat acids, cholesterol, triglycerides;
- Reactive oxygen species and nitrogen reactive species;
- Oxidative phosphorylation (OXPHOS) as a major metabolic pathway, uncoupled respiration;
- Electron transport chain (ETC) in mitochondria;
- Krebs or tricarboxylic acid (TCA) cycle and glycolysis;
- The role of NADH and PARP;
- Persistent inflammatory, immunosuppressed, catabolic syndrome;
- Metabolic reprogramming.
Prof. Dr. Francisco Garcia Soriano
Prof. Dr. Marisa Passarelli
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- sepsis
- inflammation
- immune metabolism
- Krebs cycle
- lipid
- cholesterol
- late sequels
- PICS
- chronicle critical disease
- genetic reprogramming
- epigenetic
