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State-of-the-Art Molecular Immunology in Chile, 2nd Edition
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State-of-the-Art Molecular Immunology in Chile, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1654

Special Issue Editors

Prof. Dr. Marcela Hernandez Ríos

E-Mail Website
Guest Editor
1. Laboratory of Periodontal Biology, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile
2. Department of Pathology and Oral Medicine, Faculty of Dentistry, University of Chile, Santiago 8380544, Chile
Interests: host–pathogen interactions; periodontitis; endodontics; oral medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Juan C. Aguillon

E-Mail Website1 Website2
Guest Editor
Immune Regulation and Tolerance Research Group, Immunology Program, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 7800003, Chile
Interests: autoantigen discovery; rheumatoid arthritis; dendritic cells
Special Issues, Collections and Topics in MDPI journals
Dr. María Rosa Bono

E-Mail Website
Guest Editor
Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile
Interests: basic immunology and autoimmunity
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Dr. Nicolas Dutzan

E-Mail Website
Guest Editor
1. Laboratory of Oral Microbiology, Faculty of Dentistry, University of Chile, Santiago 7800003, Chile
2. Conservative Dentistry Department, Faculty of Dentistry, University of Chile, Santiago 7800003, Chile
Interests: mucosal immunology; cytokines; T helper cells; oral mucosa; periodontitis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Rolando Vernal

E-Mail Website
Guest Editor
Periodontal Biology Laboratory, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile
Interests: osteoimmunology; dentistry; oral microbiology; alveolar bone loss; alveolar bone resorption; alveolar bone regeneration
Special Issues, Collections and Topics in MDPI journals
Dr. Leandro J. Carreño

E-Mail Website
Guest Editor
Millennium Institute on Immunology and Immunotherapy, Programa de Inmunología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile
Interests: natural killer T cells; T cells; B cells; inflammation; allergy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue follows the publication of the first edition on “State-of-the-Art Molecular Immunology in Chile”.

The immune system is a highly integrated array of molecular and cellular components that has evolved to protect the host from disease. Its functions are divided up into two main arms: the innate immune system, as the first line of non-specific defense, and the adaptive immune system, involving enhanced responses to specific pathogens, cells, or foreign substances. If the immune balance is disturbed, it can lead to disease. Molecular-level basic and clinical research in this area involves autoimmunity, immunodeficiency, allergies, infectious-inflammatory diseases, neuroimmunology, and cancer. Additionally, emerging knowledge on the immune system is contributing to developing new therapies, such as immunotherapy, monoclonal antibodies, and vaccines, which either block or prime the immune system to manage or eliminate the disease. This Special Issue of IJMS aims to provide a comprehensive view of “Recent Advances in Molecular Immunology in Chile”. We invite research and review papers that will consolidate our understanding in this area. Potential topics include, but are not limited to, the following:

  • Host–pathogen interactions;
  • Innate immunity;
  • Adaptive immunity;
  • Immunopathology;
  • Cancer immunology;
  • Neuroimmunology;
  • Osteoimmunology;
  • Immunosenescence;
  • Immunomodulation;
  • Immunotherapy;
  • Antibody therapy;
  • Vaccines.

Prof. Dr. Marcela Hernandez Ríos
Dr. Juan C. Aguillon
Dr. María Rosa Bono
Dr. Nicolas Dutzan
Prof. Dr. Rolando Vernal
Dr. Leandro J. Carreño
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • innate immunity
  • adaptive immunity
  • host–pathogen interactions
  • immunopathology
  • osteoimmunology
  • immunosenescence
  • immunotherapy
  • antibody
  • vaccines
  • Chile

Published Papers (2 papers)

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Research

15 pages, 2664 KiB  
Article
Differential Response of Human Dendritic Cells upon Stimulation with Encapsulated or Non-Encapsulated Isogenic Strains of Porphyromonas gingivalis
by Samanta Melgar-Rodríguez, Alan Polanco, Jearitza Ríos-Muñoz, Michelle García, Alfredo Sierra-Cristancho, Luis González-Osuna, Jaime Díaz-Zúñiga, Paola Carvajal, Rolando Vernal and Denisse Bravo
Int. J. Mol. Sci. 2024, 25(8), 4510; https://doi.org/10.3390/ijms25084510 - 20 Apr 2024
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Abstract
During periodontitis, the extracellular capsule of Porphyromonas gingivalis favors alveolar bone loss by inducing Th1 and Th17 patterns of lymphocyte response in the infected periodontium. Dendritic cells recognize bacterial antigens and present them to T lymphocytes, defining their activation and polarization. Thus, dendritic [...] Read more.
During periodontitis, the extracellular capsule of Porphyromonas gingivalis favors alveolar bone loss by inducing Th1 and Th17 patterns of lymphocyte response in the infected periodontium. Dendritic cells recognize bacterial antigens and present them to T lymphocytes, defining their activation and polarization. Thus, dendritic cells could be involved in the Th1 and Th17 response induced against the P. gingivalis capsule. Herein, monocyte-derived dendritic cells were obtained from healthy individuals and then stimulated with different encapsulated strains of P. gingivalis or two non-encapsulated isogenic mutants. Dendritic cell differentiation and maturation were analyzed by flow cytometry. The mRNA expression levels for distinct Th1-, Th17-, or T-regulatory-related cytokines and transcription factors, as well as TLR2 and TLR4, were assessed by qPCR. In addition, the production of IL-1β, IL-6, IL-23, and TNF-α was analyzed by ELISA. The encapsulated strains and non-encapsulated mutants of P. gingivalis induced dendritic cell maturation to a similar extent; however, the pattern of dendritic cell response was different. In particular, the encapsulated strains of P. gingivalis induced higher expression of IRF4 and NOTCH2 and production of IL-1β, IL-6, IL-23, and TNF-α compared with the non-encapsulated mutants, and thus, they showed an increased capacity to trigger Th1 and Th17-type responses in human dendritic cells. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Immunology in Chile, 2nd Edition)
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12 pages, 741 KiB  
Article
Association of Periodontitis and Atopic Dermatitis with the Levels of IL-13, IL-31, and TSLP in the Gingival Crevicular Fluid
by Constanza Jiménez, Javier Fernández, Marcela Aroca, María José Bordagaray, Elizabeth Pellegrini, Javier Contador, Marcela Hernández, Fernando Valenzuela and Alejandra Fernández
Int. J. Mol. Sci. 2023, 24(21), 15592; https://doi.org/10.3390/ijms242115592 - 26 Oct 2023
Viewed by 911
Abstract
Emerging epidemiological evidence links atopic dermatitis (AD) and periodontitis, although the mechanisms remain unclear. Th2-derived cytokines are key in the development of both diseases, and different gingival crevicular fluid (GCF) profiles among healthy and diseased subjects have been previously reported. This case–control study [...] Read more.
Emerging epidemiological evidence links atopic dermatitis (AD) and periodontitis, although the mechanisms remain unclear. Th2-derived cytokines are key in the development of both diseases, and different gingival crevicular fluid (GCF) profiles among healthy and diseased subjects have been previously reported. This case–control study examined the GCF levels of interleukins (IL)-13, IL-31, and thymic stromal lymphopoietin (TSLP) in 29 subjects with moderate-to-severe AD and 33 controls. All subjects underwent comprehensive clinical and oral evaluations, followed by GCF collection. GCF levels of IL-13, IL-31, and TSLP were assessed using a multiplex-bead immunoassay. Demographic and periodontal parameters were similar among groups (p > 0.05). The GCF levels of IL-31 and TSLP were higher in AD subjects compared to controls (p < 0.05), whereas no significant differences in the GCF levels of IL-13 were noticed (p = 0.377). Moderate-to-severe AD was positively associated with the GCF levels of IL-31 and TSLP, whereas severe periodontitis was negatively associated with IL-31 (p < 0.05). The GCF levels of IL-13 showed no significant associations with either condition (p = 0.689). There was no significant interaction between AD and periodontitis for IL-31 (p < 0.869). These results suggest that AD and periodontitis independently influence the GCF levels of IL-31 in opposing ways, whereas AD alone influences the levels of TSLP. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Immunology in Chile, 2nd Edition)
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