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Molecular Research of Viral Gastroenteritis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4121

Special Issue Editors


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Guest Editor
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Tokyo 173-8610, Japan
Interests: clinical immunology; infection immunology

E-Mail Website
Guest Editor
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Tokyo 173-8610, Japan
Interests: pediatric viral infections

Special Issue Information

Dear Colleagues,

Although it has been secondary to COVID-19 over the past few years, viral gastroenteritis remains a major global threat. It is the leading cause of child mortality, especially in developing countries, and this has been exacerbated by the strain that COVID-19 has placed on healthcare resources. Against rotavirus, an effective prophylactic vaccine has been developed. However, the norovirus vaccine is not yet available. In addition, new mutant strains being replaced these viruses and the emergence of new viruses (such as sapoviruses and bocaviruses) pose a threat. In this Special Issue, we will discuss virus mutations, molecular epidemiological analysis, host immune responses, environmental factors, zoonotic aspects, and the role of the intestinal microbiome. Developing rapid and accurate molecular diagnostic methods, bedside or laboratory markers of serious complications (such as encephalopathy and sepsis), and novel antiviral medications is crucial from a clinical standpoint. This Special Issue seeks to establish the molecular virological landmarks of the first two decades of the 21st century and aims to await clarification.

Prof. Dr. Satoshi Hayakawa
Prof. Dr. Hiroshi Ushijima
Guest Editors

Manuscript Submission Information

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Keywords

  • viral enterocolitis
  • molecular epidemiology
  • host immune response and microbiome
  • serious systemic complications
  • novel vaccines and therapeutics
  • rapid molecular diagnosis
  • one health and zoonotic infections
  • food and water hygiene

Published Papers (2 papers)

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Research

21 pages, 5014 KiB  
Article
Surveillance of Human Rotaviruses in Wuhan, China (2019–2022): Whole-Genome Analysis of Emerging DS-1-like G8P[8] Rotavirus
by Xuan Zhou, Yuanhong Wang, Nan Chen, Beibei Pang, Manqing Liu, Kun Cai and Nobumichi Kobayashi
Int. J. Mol. Sci. 2023, 24(15), 12189; https://doi.org/10.3390/ijms241512189 - 29 Jul 2023
Cited by 2 | Viewed by 1206
Abstract
Group A rotaviruses (RVAs) are major etiologic agents of gastroenteritis in infants and young children worldwide. To study the prevalence and genetic characteristics of RVAs, a hospital-based surveillance study was conducted in Wuhan, China from June 2019 through May 2022. The detection rates [...] Read more.
Group A rotaviruses (RVAs) are major etiologic agents of gastroenteritis in infants and young children worldwide. To study the prevalence and genetic characteristics of RVAs, a hospital-based surveillance study was conducted in Wuhan, China from June 2019 through May 2022. The detection rates of RVAs were 19.40% (142/732) and 3.51% (8/228) in children and adults, respectively. G9P[8] was the predominant genotype, followed by G8P[8] and G3P[8]. G8P[8] emerged and was dominant in the 2021–2022 epidemic season. The genome constellation of six G8P[8] strains was assigned to G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that the VP7, VP4, VP2, VP3, NSP1, NSP2, NSP3, and NSP5 genes of these G8P[8] strains clustered closely with those of the G8P[8] strains in Asia and were distant from those of the P[8] and G2P[4] strains simultaneously detected in Wuhan. In contrast, the VP1, VP6, and NSP4 genes were closely related to the typical G2P[4] rotavirus, including those of G2P[4] strains simultaneously detected in Wuhan. The detection rate of RVAs decreased in the COVID-19 pandemic era. It was deduced that the G8P[8] rotaviruses that emerged in China may be reassortants, carrying the VP6, VP1, and NSP4 genes derived from the G2P[4] rotavirus in the backbone of the neighboring DS-1-like G8P[8] strains represented by CAU17L-103. Full article
(This article belongs to the Special Issue Molecular Research of Viral Gastroenteritis)
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7 pages, 802 KiB  
Communication
A Comparative Study of Acute Gastroenteritis Symptoms in Single- versus Multiple-Virus Infections
by Toshiyuki Hikita, Tung Phan, Shoko Okitsu, Satoshi Hayakawa and Hiroshi Ushijima
Int. J. Mol. Sci. 2023, 24(9), 8364; https://doi.org/10.3390/ijms24098364 - 06 May 2023
Cited by 2 | Viewed by 2323
Abstract
Many different enteric viruses can cause acute gastroenteritis in humans worldwide. While a single virus can indeed cause disease, multiple-virus infections are commonly reported. However, data regarding a comparison between single- and multiple-virus infections upon clinical manifestations of acute gastroenteritis are relatively limited. [...] Read more.
Many different enteric viruses can cause acute gastroenteritis in humans worldwide. While a single virus can indeed cause disease, multiple-virus infections are commonly reported. However, data regarding a comparison between single- and multiple-virus infections upon clinical manifestations of acute gastroenteritis are relatively limited. In this study, a total of 2383 fecal specimens were collected from children with acute gastroenteritis during June 2014–July 2017 in a pediatric clinic in Japan and tested for 11 viruses by multiplex RT-PCR. At least 1 virus was found in 1706 (71.6%) specimens and norovirus GII was the most frequent agent, followed by rotavirus A and other viruses. Multiple-virus infections were identified in 565 cases (33.1%). While major clinical symptoms were found to be significantly different in some single- vs. multiple-virus infections, the disease severity was statistically non-significant. Our study highlights the burden of multiple-virus infections for acute gastroenteritis and the clinical features of patients with multiple-virus infections. Full article
(This article belongs to the Special Issue Molecular Research of Viral Gastroenteritis)
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