Liver-Gut Axis 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2282
Special Issue Editor
Interests: leaky gut; endotoxin; nonalcoholic fatty liver disease; alcoholic liver disease; liver fibrosis; Toll-like receptors; probiotics; antibiotics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gut-derived nutrients and other signals are delivered to the liver via the portal circulation. As the largest immune organ, the liver hosts the entire spectrum of immune-cell repertoire. It has a remarkable capacity to recruit and activate immune cells in response to gut-derived metabolic or pathogen-derived signals. The crosstalk between the gut and the liver is increasingly recognized, strengthened by the parallel rise in liver diseases and gastrointestinal and immune disorders. The gut–liver axis is widely implicated in the pathogenesis of liver disease, including alcoholic liver disease, nonalcoholic fatty liver disease, primary biliary cholangitis, cirrhosis, hepatocellular carcinoma, and acute-on-chronic liver failure. The risk of damage to the liver increases when the intestinal barrier is damaged (“leaky gut”). Intestinal dysbiosis plays an important role in the development of chronic liver disease. The gut–liver axis has evolved from basic research to therapeutic strategies to improve the prognosis of chronic liver diseases. Further research on the gut–liver axis has led to new insights into the pathogenesis of liver disease and therapeutic strategies.
This Special Issue will be dedicated to the “Liver–Gut Axis”; it welcomes submissions, including original papers and reviews, on these widely discussed topics.
Dr. Takemi Akahane
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- dysbiosis
- leaky gut
- gastrointestinal microbiome
- endotoxin
- antibiotics
- probiotics
- chronic liver disease
- liver fibrosis
- acute-on-chronic liver failure
- hepatocellular carcinoma
