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Recent Advances on Synapses

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 1518

Special Issue Editor


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Guest Editor
Neurophysiology and Plasticity Unit, IRCCS-Fondazione Santa Lucia, 00143 Rome, Italy
Interests: synaptic transmission; plasticity; electrophysiology; movement disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The synapses perform several important functions in the nervous system that include the development and the normal activity of neurons. Rapidly, the presynaptic terminal transfers the information with a complex mechanism of neurotransmitter release, and postsynaptic specialization senses neurotransmitters through a diverse repertoire of receptors. Multiple lines of the experimental analysis suggest that different molecules provide additional support to maintain the activity of synapses. Their formation and action are finely regulated at the cellular and extra-cellular levels. It seems likely that independent molecules and different glial cell types enable to promote the correct formation and maturation of the neuronal synapses with a strong influence of plasticity induction. The purpose of the present special issue is to collect original articles, reviews, case reports, and scientific communications that investigate through multidisciplinary approaches the mechanisms underlying the recent advances in neuronal synapses such as molecular composition, structural organization, signaling function, and plasticity induction during the normal physiological role of synapses or during various dysfunction that may manifest in the different neurological disorders.

Dr. Annalisa Tassone
Guest Editor

Manuscript Submission Information

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Keywords

  • synapse
  • neurotransmission
  • plasticity
  • signaling function
  • development
  • machine release
  • neuron function

Published Papers (1 paper)

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7 pages, 2323 KiB  
Opinion
Are Voltage Sensors Really Embedded in Muscarinic Receptors?
by Malka Cohen-Armon
Int. J. Mol. Sci. 2023, 24(8), 7538; https://doi.org/10.3390/ijms24087538 - 19 Apr 2023
Viewed by 1096
Abstract
Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor, acting as a voltage sensor. However, this explanation is inconsistent with the [...] Read more.
Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor, acting as a voltage sensor. However, this explanation is inconsistent with the results of experiments measuring acetylcholine binding to muscarinic receptors in brain synaptoneurosomes. According to these results, the gating of the voltage-dependent sodium channel (VDSC) acts as the voltage sensor, generating activation of Go-proteins in response to membrane depolarization, and this modulates the affinity of muscarinic receptors for their cholinergic agonists. Full article
(This article belongs to the Special Issue Recent Advances on Synapses)
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