The Janus Faced Role of RAGE in Physiological and Pathological Conditions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3738
Special Issue Editor
Interests: muscle precursor cells; muscle regeneration; sarcopenia; cancer cachexia; muscular dystrophy; natural compounds; HMGB1; RAGE (receptor for advanced glycation end-products)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The multiligand receptor, RAGE (Receptor for Advanced Glycation End-products) is a key mediator of several physiological and pathological processes. An appropriate recruitment of RAGE concurs to correct embryonic development, regeneration/repair of injured tissues, and the resolution of inflammation. On the other hand, re-expression and over-stimulation of RAGE in adult tissues contributes to tissue damage by promoting chronic inflammation and pathogenic states, such as diabetes, cardiovascular diseases, neurodegeneration and cancer.
This Special Issue of the International Journal of Molecular Sciences aims to bring together review and original article on “The Janus-faced role of RAGE in physiological and pathological conditions”. It will focus on the mechanisms at the basis of the opposite behavior of RAGE, including alternative activation of signaling pathways, cell types, availability of specific ligands in local environment, phosphorylation state and cellular localization of RAGE, interactions between RAGE and certain adaptor proteins or other receptors, and the density of RAGE on the cell surface.
Prof. Dr. Francesca Riuzzi
Guest Editor
Manuscript Submission Information
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Keywords
- RAGE
- S100 proteins
- HMGB1
- AGEs
- DAMPs
- PAMPs
- Signalling
- Inflammation
- Development
- Regeneration
- Repair
- Cancer
- Diabetes
- Nervous system
- Infection
- Tissue damage
- Muscle tissue
- RAGE inhibitors
- Diseases
- Obesity
