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Lipid Molecules in Inflammation and Chronic Diseases 2.0
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Lipid Molecules in Inflammation and Chronic Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 4328

Special Issue Editor

Prof. Dr. Yong-Moon Lee

E-Mail Website
Guest Editor
College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
Interests: sphingolipid metabolites; inflammation; chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endogenous lipid molecules in the wide range of biological processes are involved in the lipid class of prostaglandins, leukotrienes, sphingolipids, steroids, phospholipids and acylglycerol derivatives. Such diverse lipids regulate inflammatory responses positively or negatively. Inflammatory signaling reversely regulates lipid metabolism and thus alters lipid composition in targeted organs such as the liver, adipose tissue, skeletal muscle, and macrophage.

Therefore, this Special Issue is focused on the interconnected networks from lipid signaling, inflammatory signaling and, the etiology related to lifestyle-related diseases, cancer, diabetes, obesity, atherosclerosis, etc. Particularly, research on the signaling pathways that connect inflammation to lipid metabolism will be welcomed.

Prof. Dr. Yong-Moon Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid signaling
  • lipid metabolism
  • inflammatory
  • pathways
  • lifestyle-related diseases

Published Papers (2 papers)

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Research

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15 pages, 2553 KiB  
Article
Increased Expression of miR-223-3p and miR-375-3p and Anti-Inflammatory Activity in HDL of Newly Diagnosed Women in Advanced Stages of Breast Cancer
by Monique de Fatima Mello Santana, Maria Isabela Bloise Alves Caldas Sawada, Aritania Sousa Santos, Mozania Reis, Jacira Xavier, Maria Lúcia Côrrea-Giannella, Andrea Harumy de Lima Hirata, Luiz Henrique Gebrim, Francisco Garcia Soriano, Cleber Pinto Camacho and Marisa Passarelli
Int. J. Mol. Sci. 2023, 24(16), 12762; https://doi.org/10.3390/ijms241612762 - 14 Aug 2023
Viewed by 1018
Abstract
The expression of inflammation-related miRs bound to high-density lipoproteins (HDLs), the anti-inflammatory activity of HDLs isolated from individuals with breast cancer, and controls were determined. Forty newly diagnosed women with breast cancer naïve of treatment and 10 control participants were included. Cholesterol-loaded bone-marrow-derived [...] Read more.
The expression of inflammation-related miRs bound to high-density lipoproteins (HDLs), the anti-inflammatory activity of HDLs isolated from individuals with breast cancer, and controls were determined. Forty newly diagnosed women with breast cancer naïve of treatment and 10 control participants were included. Cholesterol-loaded bone-marrow-derived macrophages were incubated with HDL from both groups and challenged with lipopolysaccharide (LPS). Interleukin 6 (IL6) and tumor necrosis factor (TNF) in the medium were quantified. The miRs in HDLs were determined by RT-qPCR. Age, body mass index, menopausal status, plasma lipids, and HDL composition were similar between groups. The ability of HDL to inhibit IL6 and TNF production was higher in breast cancer compared to controls, especially in advanced stages of the disease. The miR-223-3p and 375-3p were higher in the HDLs of breast cancer independent of the histological type of the tumor and had a high discriminatory power between breast cancer and controls. The miR-375-3p was greater in the advanced stages of the disease and was inversely correlated with the secretion of inflammatory cytokines. Inflammation-related miRs and the anti-inflammatory role of HDLs may have a significant impact on breast cancer pathophysiology. Full article
(This article belongs to the Special Issue Lipid Molecules in Inflammation and Chronic Diseases 2.0)
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Review

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16 pages, 1943 KiB  
Review
Roles of Resolvins in Chronic Inflammatory Response
by Chang Liu, Dancai Fan, Qian Lei, Aiping Lu and Xiaojuan He
Int. J. Mol. Sci. 2022, 23(23), 14883; https://doi.org/10.3390/ijms232314883 - 28 Nov 2022
Cited by 10 | Viewed by 2919
Abstract
An inflammatory response is beneficial to the organism, while an excessive uncontrolled inflammatory response can lead to the nonspecific killing of tissue cells. Therefore, promoting the resolution of inflammation is an important mechanism for protecting an organism suffering from chronic inflammatory diseases. Resolvins [...] Read more.
An inflammatory response is beneficial to the organism, while an excessive uncontrolled inflammatory response can lead to the nonspecific killing of tissue cells. Therefore, promoting the resolution of inflammation is an important mechanism for protecting an organism suffering from chronic inflammatory diseases. Resolvins are a series of endogenous lipid mediums and have the functions of inhibiting a leukocyte infiltration, increasing macrophagocyte phagocytosis, regulating cytokines, and alleviating inflammatory pain. By promoting the inflammation resolution, resolvins play an irreplaceable role throughout the pathological process of some joint inflammation, neuroinflammation, vascular inflammation, and tissue inflammation. Although a large number of experiments have been conducted to study different subtypes of resolvins in different directions, the differences in the action targets between the different subtypes are rarely compared. Hence, this paper reviews the generation of resolvins, the characteristics of resolvins, and the actions of resolvins under a chronic inflammatory response and clinical translation of resolvins for the treatment of chronic inflammatory diseases. Full article
(This article belongs to the Special Issue Lipid Molecules in Inflammation and Chronic Diseases 2.0)
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