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Nanotechnology in Targeted Drug Delivery 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 1830

Special Issue Editors


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Guest Editor
Department of Pharmacy, University G. d’Annunzio, Via dei Vestini, 66100 Chieti, Italy
Interests: drug delivery systems; CNS drug delivery; neurodegenerative disorders
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmacy, University “G. d'Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Interests: antimicrobials; anti-biofilm strategies; drug delivery systems; formulations; lipid-based nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The application of nonotechnology has aroused interest to improve the effectiveness of therapies for a variety of diseases difficult to treat in a conventional way. In this context, nanostructured materials have been proposed as suitable approach employed in the drug delivery to cross physiological barriers, thus increasing bioavailability, biodistribution, and accumulation of therapeutics preferentially in the target diseased area, acting as stability enhancers. Furthermore it is interesting their increasing application in various biomedical fields such as tissue engineering, and medical diagnosis. Starting from these evidences, this Special Issue aims to highlight the latest achievements and current progresses useful to implement the scientific knowledge in the field of targeted drug delivery. For this purpose, we encourage scientists from worldwide to present their work as scientific contribution or review articles. We will really appreciate your valuable contributions and it will be a pleasure to collect them.

Prof. Dr. Antonio Di Stefano
Dr. Marilisa Pia Dimmito
Guest Editors

Manuscript Submission Information

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Keywords

  • pharmaceutical materials
  • functionalization
  • nanoformulations
  • drug release

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Published Papers (1 paper)

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Review

33 pages, 2107 KiB  
Review
From Benznidazole to New Drugs: Nanotechnology Contribution in Chagas Disease
by Daniele Cavalcante Gomes, Thayse Silva Medeiros, Eron Lincoln Alves Pereira, João Felipe Oliveira da Silva, Johny W. de Freitas Oliveira, Matheus de Freitas Fernandes-Pedrosa, Marcelo de Sousa da Silva and Arnóbio Antônio da Silva-Júnior
Int. J. Mol. Sci. 2023, 24(18), 13778; https://doi.org/10.3390/ijms241813778 - 7 Sep 2023
Cited by 2 | Viewed by 1544
Abstract
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both drugs present side effects and efficacy problems, especially in the chronic phase of this disease. Therefore, [...] Read more.
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both drugs present side effects and efficacy problems, especially in the chronic phase of this disease. Therefore, new molecules have been tested with promising results aiming for strategic targeting action against T. cruzi. Several studies involve in vitro screening, but a considerable number of in vivo studies describe drug bioavailability increment, drug stability, toxicity assessment, and mainly the efficacy of new drugs and formulations. In this context, new drug delivery systems, such as nanotechnology systems, have been developed for these purposes. Some nanocarriers are able to interact with the immune system of the vertebrate host, modulating the immune response to the elimination of pathogenic microorganisms. In this overview of nanotechnology-based delivery strategies for established and new antichagasic agents, different strategies, and limitations of a wide class of nanocarriers are explored, as new perspectives in the treatment and monitoring of Chagas disease. Full article
(This article belongs to the Special Issue Nanotechnology in Targeted Drug Delivery 2.0)
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