ijms-logo

Journal Browser

Journal Browser

Quantitative Identification and Action-Mechanisms of Anti-cancer and Anti-inflammatory Natural Compounds 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 886

Special Issue Editors

College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea
Interests: molecular biology; drug metabolism; drug toxicity; carcinogenesis; cancer metastasis; chemoprevention; post translational modifications; transcriptional regulation; immune regulation; inflammation; biomarkers
Special Issues, Collections and Topics in MDPI journals
Laboratory of Pharmacotherapy, College of Pharmacy, Chungnam National University, Daehak-ro 99, Yuseong-gu, Daejeon 34134, Republic of Korea
Interests: pharmacometrics; systems pharmacology; modeling and simulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the upcoming release of a third volume of “Quantitative Identification and Action-Mechanisms of Anti-cancer and Anti-inflammatory Natural Compounds 3.0”, published in IJMS. It is our hope that this volume will inherit the outstanding success of our previous Special Issue. Despite 32 outstanding papers being published in the second volume of the SI, it remains possible to of publish further high-quality work. We sincerely encourage all researchers in related fields with an interest in this Special Issue to contribute their original research. Many natural substances have been discovered which possess pharmacological activity, especially of anticancer and anti-inflammatory varieties. Despite those discoveries, there remain limitations to making those for drugs and health supplements since their efficacy when combined the appropriate disease animal model, identification of their molecular mechanisms, and quantification of exposures and pharmacological behaviors must be validated. This Special Issue aims to cover a selection of research papers and reviews that expand knowledge from recently discovered natural resources with anticancer and anti-inflammatory activity to incorporate new quantitative identification of natural resources in the body. In addition, new evaluation methods for the above fields will also be covered. Therefore, we sincerely welcome not only studies on searching novel natural compounds with anticancer and anti-inflammatory activity, but also studies on the evaluation of efficacy of natural compounds, elucidation of mechanisms of action, identification of molecular targets, enhancement of bioactivity via derivatization or pharmaceutical formulation, and the new characterization of the pharmacokinetics and pharmacodynamics of known bioactive natural compounds.

Prof. Dr. Hye Gwang Jeong
Prof. Dr. Hwi-Yeol Yun
Prof. Dr. Hangun Kim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • anti-inflammatory
  • natural compounds
  • efficacy
  • mechanism of action
  • molecular target
  • bioactivity
  • pharmacokinetics
  • pharmacodynamics

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 4514 KiB  
Article
Antarctic Krill Oil from Euphausia superba Ameliorates Carrageenan-Induced Thrombosis in a Mouse Model
Int. J. Mol. Sci. 2023, 24(24), 17440; https://doi.org/10.3390/ijms242417440 - 13 Dec 2023
Viewed by 654
Abstract
FJH-KO obtained from Antarctic krill, especially Euphausia superba, has been reported to contain high amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and to exhibit anticancer and anti-inflammatory properties. However, its antithrombotic effects have not yet been reported. This study aimed to [...] Read more.
FJH-KO obtained from Antarctic krill, especially Euphausia superba, has been reported to contain high amounts of omega-3 polyunsaturated fatty acids (n-3 PUFA) and to exhibit anticancer and anti-inflammatory properties. However, its antithrombotic effects have not yet been reported. This study aimed to investigate the antithrombotic effects of FJH-KO in carrageenan-induced thrombosis mouse models and human endothelial cells. Thrombosis was induced by carrageenan injection, whereas the mice received FJH-KO pretreatment. FJH-KO attenuated carrageenan-induced thrombus formation in mouse tissue vessels and prolonged tail bleeding. The inhibitory effect of FJH-KO was associated with decreased plasma levels of thromboxane B2, P-selectin, endothelin-1, β-thromboglobulin, platelet factor 4, serotonin, TNF-α, IL-1β, and IL-6. Meanwhile, FJH-KO induced plasma levels of prostacyclin I2 and plasminogen. In vitro, FJH-KO decreased the adhesion of THP-1 monocytes to human endothelial cells stimulated by TNF-α via eNOS activation and NO production. Furthermore, FJH-KO inhibited the expression of TNF-α-induced adhesion molecules such as ICAM-1 and VCAM-1 by suppressing the NF-κB signaling pathway. Taken together, our study demonstrates that FJH-KO protects against carrageenan-induced thrombosis by regulating endothelial cell activation and has potential as an antithrombotic agent. Full article
Show Figures

Figure 1

Back to TopTop