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Mechanisms and Therapeutics of Platelet Thrombus Formation 2020
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Mechanisms and Therapeutics of Platelet Thrombus Formation 2020

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 14493

Special Issue Editor

Prof. Dr. Denise Jackson

E-Mail Website
Guest Editor
Discipline Leader and Program Leader of Laboratory Medicine, BP147 Program Co-ordinator, Head of Thrombosis and Vascular Diseases Laboratory, School of Health and Biomedical Sciences, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
Interests: thrombosis; platelet biology; mouse models; human platelets; anti-platelet therapy; biochemistry; atherosclerosis; vascular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Platelets are normally free flowing in a blood vessel. However, in the event of vessel injury or disease, such as atherosclerotic plaques, platelets will initially tether, via exposed extracellular matrix ligands, with respective platelet receptors; then adhesive events occur; followed by activation through signalling events. These inside–out signalling events lead to the conversion of the major platelet integrin alphaIIbbeta3 from a resting to an activated state, where it will bind its natural ligands, including fibrinogen, to create stable platelet aggregates. The numerous steps involved in platelet thrombus formation are regulated by different receptors, ligands, signalling molecules, rheological biomechanical forces, and soluble agonist-dependent mechanisms. These events regulate not only thrombus growth and stability, but also the propagation of blood clots formed. In addition, papers that evaluate new technologies or new therapeutics that modulate thrombus formation will be also be considered.

Prof. Dr. Denise Jackson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelet adhesion
  • platelet aggregation
  • tissue factor bearing microparticles
  • thrombus growth
  • thrombus stability
  • platelet tethering
  • platelet activation
  • propagation of thrombus formation
  • rheological biomechanical platelet aggregation
  • soluble agonist dependent mechanisms

Related Special Issue

Published Papers (3 papers)

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Research

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21 pages, 4160 KiB  
Article
Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate
by Augusto Martins Lima, Damian S. Saint Auguste, François Cuenot, Ana C. Martins Cavaco, Tom Lachkar, Cindy Marie Elodie Khawand, Rodrigo A. Fraga-Silva and Nikolaos Stergiopulos
Int. J. Mol. Sci. 2020, 21(18), 6539; https://doi.org/10.3390/ijms21186539 - 07 Sep 2020
Cited by 4 | Viewed by 3132
Abstract
Platelets play a crucial role in the immunological response and are involved in the pathological settings of vascular diseases, and their adhesion to the extracellular matrix is important to bring leukocytes close to the endothelial cells and to form and stabilize the thrombus. [...] Read more.
Platelets play a crucial role in the immunological response and are involved in the pathological settings of vascular diseases, and their adhesion to the extracellular matrix is important to bring leukocytes close to the endothelial cells and to form and stabilize the thrombus. Currently there are several methods to study platelet adhesion; however, the optimal parameters to perform the assay vary among studies, which hinders their comparison and reproducibility. Here, a standardization and validation of a fluorescence-based quantitative adhesion assay to study platelet-ECM interaction in a high-throughput screening format is proposed. Our study confirms that fluorescence-based quantitative assays can be effectively used to detect platelet adhesion, in which BCECF-AM presents the highest sensitivity in comparison to other dyes. Full article
(This article belongs to the Special Issue Mechanisms and Therapeutics of Platelet Thrombus Formation 2020)
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Review

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14 pages, 953 KiB  
Review
Lipids and Antiplatelet Therapy: Important Considerations and Future Perspectives
by Nina Đukanović, Slobodan Obradović, Marija Zdravković, Siniša Đurašević, Maja Stojković, Tomislav Tosti, Nebojša Jasnić, Jelena Đorđević and Zoran Todorović
Int. J. Mol. Sci. 2021, 22(6), 3180; https://doi.org/10.3390/ijms22063180 - 20 Mar 2021
Cited by 8 | Viewed by 3175
Abstract
Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in [...] Read more.
Lipids play an essential role in platelet functions. It is known that polyunsaturated fatty acids play a role in increasing platelet reactivity and that the prothrombotic phenotype plays a crucial role in the occurrence of major adverse cardiovascular events. The ongoing increase in cardiovascular diseases’ incidence emphasizes the importance of research linking lipids and platelet function. In particular, the rebound phenomenon that accompanies discontinuation of clopidogrel in patients receiving dual antiplatelet therapy has been associated with changes in the lipid profile. Our many years of research underline the importance of reduced HDL values for the risk of such a rebound effect and the occurrence of thromboembolic events. Lipids are otherwise a heterogeneous group of molecules, and their signaling molecules are not deposited but formed “on-demand” in the cell. On the other hand, exosomes transmit lipid signals between cells, and the profile of such changes can be monitored by lipidomics. Changes in the lipid profile are organ-specific and may indicate new drug action targets. Full article
(This article belongs to the Special Issue Mechanisms and Therapeutics of Platelet Thrombus Formation 2020)
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24 pages, 1817 KiB  
Review
Targeting Platelet in Atherosclerosis Plaque Formation: Current Knowledge and Future Perspectives
by Lei Wang and Chaojun Tang
Int. J. Mol. Sci. 2020, 21(24), 9760; https://doi.org/10.3390/ijms21249760 - 21 Dec 2020
Cited by 37 | Viewed by 7563
Abstract
Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites [...] Read more.
Besides their role in hemostasis and thrombosis, it has become increasingly clear that platelets are also involved in many other pathological processes of the vascular system, such as atherosclerotic plaque formation. Atherosclerosis is a chronic vascular inflammatory disease, which preferentially develops at sites under disturbed blood flow with low speeds and chaotic directions. Hyperglycemia, hyperlipidemia, and hypertension are all risk factors for atherosclerosis. When the vascular microenvironment changes, platelets can respond quickly to interact with endothelial cells and leukocytes, participating in atherosclerosis. This review discusses the important roles of platelets in the plaque formation under pro-atherogenic factors. Specifically, we discussed the platelet behaviors under disturbed flow, hyperglycemia, and hyperlipidemia conditions. We also summarized the molecular mechanisms involved in vascular inflammation during atherogenesis based on platelet receptors and secretion of inflammatory factors. Finally, we highlighted the studies of platelet migration in atherogenesis. In general, we elaborated an atherogenic role of platelets and the aspects that should be further studied in the future. Full article
(This article belongs to the Special Issue Mechanisms and Therapeutics of Platelet Thrombus Formation 2020)
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