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Molecular Research for Personalized Antitumoral Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2126

Special Issue Editor


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Guest Editor
Fondazione Policlinico Universitario A. Gemelli, IRCCS, Dipartimento di Scienze della vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
Interests: molecular pathology; neuro-oncology; hematopathology; molecular diagnosis in oncology

Special Issue Information

Dear Colleagues,

Precision oncology is no longer a futuristic approach to therapy as it has become an important part of clinical practice for physicians and scientists to assess diagnostic targets for personalized medicine. Although precision medicine is not a routinary path for most oncological patients, increased understanding of oncological diagnosis with genetics-based patient stratification will contribute to the future steps of precision oncology. Furthermore, the development of new antitumoral agents targeting specific genetic changes is a fundamental part of precision oncology, in particular for hematological malignancies, CNS glial neoplasms and head-and-neck tumors, as well as urothelial neoplasms.

In this context, this Special Issue aims to cover all sectors of research based on molecular patterns for antitumoral therapy. It will include original research, review articles, and short communications on specific molecular mechanisms of antitumoral agents, including conventional chemotherapeutical drugs, novel potential antitumoral drug candidates, and their combinations with any other antitumoral modalities.

Prof. Dr. Luigi Maria Larocca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision oncology
  • hematological malignancies
  • CNS glial neoplasms
  • head-and-neck tumors
  • urothelial neoplasms
  • antitumoral agents
  • antitumoral therapy

Published Papers (1 paper)

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Review

12 pages, 1359 KiB  
Review
DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis
by Vincenzo Fiorentino, Patrizia Straccia, Pietro Tralongo, Teresa Musarra, Francesco Pierconti, Maurizio Martini, Guido Fadda, Esther Diana Rossi and Luigi Maria Larocca
Int. J. Mol. Sci. 2022, 23(17), 9711; https://doi.org/10.3390/ijms23179711 - 26 Aug 2022
Viewed by 1828
Abstract
DOG1 is a transmembrane protein originally discovered on gastrointestinal stromal tumors and works as a calcium-activated chloride channel protein. There are a limited number of articles on the potential utility of this antibody in the diagnosis of salivary gland tumors in routine practice. [...] Read more.
DOG1 is a transmembrane protein originally discovered on gastrointestinal stromal tumors and works as a calcium-activated chloride channel protein. There are a limited number of articles on the potential utility of this antibody in the diagnosis of salivary gland tumors in routine practice. In this study, we aimed to investigate the role of DOG1 as an immunohistochemical marker in patients with salivary acinic cell carcinoma (ACC) through meta-analysis. A literature search was performed of the PubMed, Scopus, and Web of Science databases for English-language studies published from January 2010 to September 2021. The literature search revealed 148 articles, of which 20 were included in the study. The overall rate of DOG1 expression in salivary acinic cell carcinoma was 55% (95% CI = 0.43–0.58). Although ACC is a challenging diagnosis, paying careful attention to the cytomorphological features in conjunction with DOG1 immunostaining can help to reach an accurate diagnosis. Full article
(This article belongs to the Special Issue Molecular Research for Personalized Antitumoral Therapy)
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