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The Angiotensin in Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 May 2024 | Viewed by 1416

Special Issue Editor


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Guest Editor
Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Interests: renin–angiotensin–aldosterone system; endocrine hypertension; adrenal gland; diabetic kidney disease

Special Issue Information

Dear Colleagues,

The renin angiotensin aldosterone system (RAAS) plays an important role in the control of body fluid and electrolyte homeostasis, as well as in blood pressure regulation. Angiotensin II is the most important effector hormone in this system and functions primarily through the stimulation of its subtype receptors, in particular the AT1 receptor. The knowledge about the involvement of other angiotensin receptors in physiological and pathological processes is still evolving. RAAS contributes to the regulation of cardiovascular, renal and metabolic functions. Additionally, RAAS regulates cellular growth and matrix formation. The imbalance of RAAS function has been linked to multiple cardiovascular, renal and metabolic diseases. This Special Issue will focus on the evolving knowledge involving RAAS activities in human health and disease.

Prof. Dr. Helmy M. Siragy
Guest Editor

Manuscript Submission Information

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Keywords

  • renin–angiotensin–aldosterone system
  • angiotensin subtype receptors
  • cardiovascular disease
  • kidney diseases
  • stroke
  • metabolic abnormalities
  • obesity and adipose tissue
  • oxidative stress and inflammation
  • blood pressure and salt sensitivity

Published Papers (1 paper)

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Review

19 pages, 1235 KiB  
Review
The Renin–Angiotensin System and Cardiovascular–Kidney–Metabolic Syndrome: Focus on Early-Life Programming
by You-Lin Tain and Chien-Ning Hsu
Int. J. Mol. Sci. 2024, 25(6), 3298; https://doi.org/10.3390/ijms25063298 - 14 Mar 2024
Viewed by 914
Abstract
The identification of pathological links among metabolic disorders, kidney ailments, and cardiovascular conditions has given rise to the concept of cardiovascular–kidney–metabolic (CKM) syndrome. Emerging prenatal risk factors seem to increase the likelihood of CKM syndrome across an individual’s lifespan. The renin–angiotensin system (RAS) [...] Read more.
The identification of pathological links among metabolic disorders, kidney ailments, and cardiovascular conditions has given rise to the concept of cardiovascular–kidney–metabolic (CKM) syndrome. Emerging prenatal risk factors seem to increase the likelihood of CKM syndrome across an individual’s lifespan. The renin–angiotensin system (RAS) plays a crucial role in maternal–fetal health and maintaining homeostasis in cardiovascular, metabolic, and kidney functions. This review consolidates current preclinical evidence detailing how dysregulation of the RAS during pregnancy and lactation leads to CKM characteristics in offspring, elucidating the underlying mechanisms. The multi-organ effects of RAS, influencing fetal programming and triggering CKM traits in offspring, suggest it as a promising reprogramming strategy. Additionally, we present an overview of interventions targeting the RAS to prevent CKM traits. This comprehensive review of the potential role of the RAS in the early-life programming of CKM syndrome aims to expedite the clinical translation process, ultimately enhancing outcomes in cardiovascular–kidney–metabolic health. Full article
(This article belongs to the Special Issue The Angiotensin in Human Health and Diseases)
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