Advances in Novel Anti-Alzheimer Drugs: Biological Target, Medicinal Chemistry and Formulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 May 2024 | Viewed by 852
Special Issue Editors
Interests: drug design; biological targets; medicinal chemistry; formulation
Interests: nanotechnology; nanoparticles; drug design
Special Issue Information
Dear Colleagues,
Alzheimer’s disease is one of the greatest health and social challenges facing our aging societies. The recent advent of immunotherapy targeting the amyloid peptide triggered a renewed interest in all areas of research in this field. Given the side effects of these biotherapies and their moderate activity, significant progress is expected from the use of new or repositioned small molecules. The wide variety of disease hallmarks offers a very broad panel of biological targets that can be used alone or in combination (polytherapy). The pharmacotechnical development of suitable formulations to improve the cerebral bioavailability of these drugs is a major technological challenge. In this context, anti-Alzheimer drug design requires contributions from different disciplines: biology, medicinal chemistry and formulation.
The aim of this Special Issue is to bring together the latest discoveries in the field of anti-Alzheimer drug design, from the discovery/validation of new biological targets to the synthesis and characterization of new molecules of therapeutic interest and the development of formulations capable of delivering active principles to the brain. Particular attention will be paid to translational approaches. The development of new methods in these research areas will also be considered. The submission of original research papers and reviews on this broad and relevant topic is warmly welcomed.
Dr. Marc Since
Prof. Dr. Aurélie Malzert-Fréon
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- Alzheimer’s disease
- drug design
- amyloid peptide
- biological targets
- medicinal chemistry
- formulation
