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Molecular Pathogenesis and Treatment of Cell Lymphomas
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Molecular Pathogenesis and Treatment of Cell Lymphomas

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 3577

Special Issue Editor

Dr. Daniele Caracciolo

E-Mail Website
Guest Editor
Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy
Interests: T-cell lymphomas; antiretroviral treatment; chemotherapy; hematological malignancies; HIV; radiation therapy; acute lymphoblastic leukemia

Special Issue Information

Dear Colleagues,

T cell lymphomas (TCLs) are highly heterogeneous tumors, displaying distinct clinical and biological features. T-cell lymphomas can develop in lymphoid tissues such as lymph nodes and spleen, or outside of lymphoid tissues (i.e., gastrointestinal tract, liver, nasal cavity, skin, and others). A similar lymphocyte called a natural killer (NK) cell shares many features with T cells. When NK cells become cancerous, the cancer is called NK or NK/T-cell lymphoma and is generally grouped with other T-cell lymphomas. 

The aim of this Special Issue is to report original research articles and reviews on any aspect of TCL, including critical signaling pathways, host immune responses, pathogenesis, and novel targeted therapies such as chemotherapy, immunotherapy, stem cell transplant, monoclonal antibodies, nucleoside analogs, protease inhibitors and signaling inhibitors .Research on the deregulation of signaling pathways controlling T-cell development, differentiation, and maturation; the remodeling of the peritumor microenvironment; and the virus-mediated rewiring of T-cell biology is highly welcomed.

Dr. Daniele Caracciolo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • T-cell lymphomas
  • natural killer (NK) cell
  • gene expression profiling
  • gene mutations
  • tumor microenvironment
  • signaling pathways
  • target therapies
  • chemotherapy
  • immunotherapy
  • stem cell transplant
  • monoclonal antibodies
  • nucleoside analogs
  • protease inhibitors
  • signaling inhibitors
  • CAR-T cells
  • T-cell acute lymphoblastic leukaemia

Published Papers (2 papers)

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Research

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13 pages, 2568 KiB  
Article
Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome
by Kelly Cristina Gomes Manfrere, Marina Passos Torrealba, Frederico Moraes Ferreira, Emanuella Sarmento Alho de Sousa, Denis Miyashiro, Franciane Mouradian Emidio Teixeira, Ricardo Wesley Alberca Custódio, Helder I. Nakaya, Yasmin Alefe Leuzzi Ramos, Mirian Nacagami Sotto, Anders Woetmann, Niels Ødum, Alberto José da Silva Duarte, José Antonio Sanches and Maria Notomi Sato
Int. J. Mol. Sci. 2023, 24(5), 4674; https://doi.org/10.3390/ijms24054674 - 28 Feb 2023
Cited by 3 | Viewed by 1906
Abstract
Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and cleave to [...] Read more.
Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B and IL-18, as key signaling molecules in the immune system, are produced in an inactive form and cleave to the active form by inflammasomes. In this study, we assessed the skin, serum, peripheral mononuclear blood cell (PBMC) and lymph-node samples of SS patients and control groups (healthy donors (HDs) and idiopathic erythroderma (IE) nodes) to investigate the inflammatory markers IL-1B and IL-18 at the protein and transcript expression levels, as potential markers of inflammasome activation. Our findings showed increased IL-1B and decreased IL-18 protein expression in the epidermis of SS patients; however, in the dermis layer, we detected increased IL-18 protein expression. In the lymph nodes of SS patients at advanced stages of the disease (N2/N3), we also detected an enhancement of IL-18 and a downregulation of IL-1B at the protein level. Moreover, the transcriptomic analysis of the SS and IE nodes confirmed the decreased expression of IL1B and NLRP3, whereas the pathway analysis indicated a further downregulation of IL1B-associated genes. Overall, the present findings showed compartmentalized expressions of IL-1B and IL-18 and provided the first evidence of their imbalance in patients with Sézary syndrome. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Treatment of Cell Lymphomas)
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Review

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15 pages, 318 KiB  
Review
A Comparison of the Fifth World Health Organization and the International Consensus Classifications of Mature T-Cell Lymphomas
by Pier Paolo Piccaluga and Shaimaa S. Khattab
Int. J. Mol. Sci. 2023, 24(18), 14170; https://doi.org/10.3390/ijms241814170 - 16 Sep 2023
Cited by 2 | Viewed by 1267
Abstract
Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms in 2001, 2008, and [...] Read more.
Peripheral T-cell lymphomas (PTCLs) are a rare subset of non-Hodgkin lymphomas that often carry significant difficulty in diagnosis and classification because of their rarity and biological complexity. Previous editions of the World Health Organization (WHO) classifications of hemopoietic neoplasms in 2001, 2008, and 2017 aimed to standardize hemopoietic neoplasm diagnosis in general. Since then, crucial clinico-pathological, immunophenotypic, and recent molecular discoveries have been made in the field of lymphomas, contributing to refining diagnostic criteria of several diseases, upgrading entities previously defined as provisional, and identifying new entities. In 2022, two different models were proposed to classify hematolymphoid neoplasms: the 5th edition of the WHO classification (WHO-HAEM5) and the International Consensus Classification (ICC). Of note, a common nosography is mandatory to ensure progress in health science and ensure the basis for a real precision medicine. In this article, the authors summarized the main differences with the previous fourth WHO edition and reviewed the main discrepancies between the two newest classifications, as far as PTCLs are concerned. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Treatment of Cell Lymphomas)
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