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Carbon Nanomedicine and Human Disease
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Carbon Nanomedicine and Human Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 2190

Special Issue Editor

Dr. Marta Kutwin

E-Mail Website
Guest Editor
Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-786 Warsaw, Poland
Interests: graphene; inorganic nanoparticles; cancer; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbon nanomaterials are a family of carbon allotropes which have been extensively explored due to their unique physicochemical and biological properties. Carbon nanomaterials show a high diversity of form, including amorphous carbon, graphite, diamonds, carbon nanotubes, graphene oxide, graphene quantum dots and fullerene. Carbon nanomaterials also shed new light on the possibility of controlled drug release, high intracellular activity and increased drug-loading capacity. The biomedical possibilities of carbon nanoparticles application seems to be unlimited, but still the possible side effects must be evaluated, especially at the molecular level.

This Special Issue aims to highlight and capture the recent progress at design and manufacture of carbon nanomaterials for biomedical applications.

We invite articles on all aspects of carbon-based nanomaterials usage in human health for this Special Issue.

It is my pleasure to invite you to contribute original research and review articles.

Dr. Marta Kutwin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon allotropes
  • graphene
  • diseases
  • cancer

Published Papers (1 paper)

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Research

15 pages, 4752 KiB  
Article
Effect of Melittin Complexes with Graphene and Graphene Oxide on Triple-Negative Breast Cancer Tumors Grown on Chicken Embryo Chorioallantoic Membrane
by Karolina Daniluk, Agata Lange, Barbara Wójcik, Katarzyna Zawadzka, Jaśmina Bałaban, Marta Kutwin and Sławomir Jaworski
Int. J. Mol. Sci. 2023, 24(9), 8388; https://doi.org/10.3390/ijms24098388 - 07 May 2023
Cited by 5 | Viewed by 1971
Abstract
One of the components of bee venom is melittin (M), which has strong lysing properties on membranes. M has high toxicity to cancer cells, but it also affects healthy cells, making it necessary to use methods for targeted delivery to ensure treatment. This [...] Read more.
One of the components of bee venom is melittin (M), which has strong lysing properties on membranes. M has high toxicity to cancer cells, but it also affects healthy cells, making it necessary to use methods for targeted delivery to ensure treatment. This research is a continuation of previous studies using graphene nanomaterials as M carriers to breast cancer cells. The studies described below are conducted on a more organized biological structure than what is found in vitro cells, namely, cancerous tumors grown on a chicken embryo chorioallantoic membrane. Caspase 3 and 8 levels are analyzed, and the level of oxidative stress markers and changes in protein expression for cytokines are examined. The results show that M complexes with nanomaterials reduce the level of oxidative stress more than M alone does, but the use of graphene (GN) as a carrier increases the level of DNA damage to a greater extent than the increase caused by M alone. An analysis of cytokine levels shows that the use of the M and GN complex increases the level of proteins responsible for inhibiting tumor progression to a greater extent than the increase occasioned by a complex with graphene oxide (GO). The results suggest that the use of GN as an M carrier may increase the toxic effect of M on structures located inside a cell. Full article
(This article belongs to the Special Issue Carbon Nanomedicine and Human Disease)
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