The Roles of VIP and PACAP: From Molecular and Genetic Studies 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 150
Special Issue Editor
Interests: VIP; PACAP; neuroprotection; neurogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent studies have shown that neuropeptides, namely VIP and PACAP, are closely related to stroke, dementias, cancers, dry syndromes, etc. This is not only the case in the central and peripheral nervous system but also in the digestive, sensory, immune, endocrine, reproductive and other systems. Additionally, the mechanism of the crisis of the disease is also in the process of being clarified by a variety of basic studies. In addition, drug discovery development becomes possible on the basis of basic research into the prevention of and therapy for these diseases. Moreover, clinical research has also begun on the derivatives of VIP and their potential use as preventive and therapeutic agents for the treatment of Alzheimer's disease. Recently, it has been suggested that PACAP also plays a major role in the degradation of the tau protein at the neuronal ends and is associated with Alzheimer’s disease. We have also found that VIP and PACAP also act on neural stem cells, particularly in the hippocampus, for nerve regeneration and neurogenesis, information which may also be applied to treat nerve regeneration in the near future.
Therefore, in this Special Issue, we wish to focus on both peptides and review the current and future basic research and clinical applications based on their use in order to better understand their roles from molecular and genetic studies. We invite experts in the field to contribute their latest research, perspectives, or reviews on this fascinating and rapidly progressing topic.
Prof. Dr. Seiji Shioda
Guest Editor
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Keywords
- VIP
- PACAP
- stroke
- Alzheimer’s disease
- cancer
- dry syndrome
