Function and Mechanism of Regulatory Non-coding RNAs in Obesity and Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 2745
Special Issue Editor
2. Channelopathy Research Center (CRC), Dongguk University School of Medicine, Ilsan 10326, Republic of Korea
Interests: mechanotransduction; cytoskeleton remodeling; proliferation; differentiation; myogenesis; sarcopenia; insulin resistance; diabetes; metabolism; glucose metabolism; lipid metabolism; metabolic diseases; energy metabolism
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Special Issue Information
Dear Colleagues,
Obesity is a rapidly growing public health problem associated with multiple chronic diseases, including type 2 diabetes, hypertension, dyslipidemia, coronary heart disease, stroke, and various cancers. Accumulating evidence has elucidated the mechanisms, such as the overload of diacylglycerol and ceramide, oxidative stress, inflammation, and mitochondrial dysfunction, involved in obesity-related diseases. However, the precise mechanisms for how obesity is linked to the pathophysiology of the above diseases are still largely unknown.
In the past decade, regulatory non-coding RNAs, such as miRNAs, siRNAs, piRNAs, and lncRNAs, have become hot issues of current molecular and cellular biology as “key modulators” in physiological processes and pathophysiological processes. They can perform cell-to-cell communication and mediate cellular processes in various ways by regulating gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels. Thus, dysregulation of non-coding RNAs results in the progression of cancers, metabolic diseases, and other complex disorders. However, despite advances in the knowledge of obesity-related diseases and non-coding RNAs, the regulation, function, and mechanism of non-coding RNAs linked to the pathogenesis of obesity-related diseases remain elusive.
This Special Issue will focus on research in discovering the function and mechanism of the regulatory non-coding RNAs in the background of obesity and the pathophysiology of obesity-related diseases. This Issue will also explore new insights into the discovery and potential application of non-coding RNAs as novel biomarkers and therapeutic targets for these diseases. We invite researchers to contribute, either with original research or review articles focusing on every aspect regarding non-coding RNAs associated with obesity and obesity-related diseases.
Prof. Dr. Wan Lee
Guest Editor
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