Molecular Mechanisms and Signaling Pathways Involved in Insulin Producing β-Cell Function
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 1775
Special Issue Editor
Special Issue Information
Dear Colleagues,
Insulin is the main regulator of glucose homeostasis; the normal function of pancreatic insulin-secreting beta-cells is crucial for maintaining glucose homeostasis in the organism. Diabetes mellitus is a heterogeneous group of disorders characterized by an excess in blood glucose levels or hyperglycemia. Defective insulin secretion is the cause of all forms of diabetes.
Genetic and environmental factors can impact beta-cell dysfunction in many ways, such as impaired glucose-sensing and secretion coupling mechanisms, insufficient adaptive response to insulin resistance, increased beta-cell loss, and dedifferentiation.
Several mechanisms have been suggested to be involved in decreased beta-cell function and/or survival in Type 2 diabetes, including oxidative stress, ceramide formation, ER overload, inflammation, disturbance of the circadian-timing system, disruption of intra-islet communication, elevated blood glucagon levels, etc.
Maintaining pancreatic beta-cell function and mass is essential for normal insulin production and glucose homeostasis.
Dr. Danielle Melloul
Guest Editor
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