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Inflammatory Responses and Immunity under Stress
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Inflammatory Responses and Immunity under Stress

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1096

Special Issue Editor

Dr. Judith-Irina Buchheim

E-Mail Website
Guest Editor
Laboratory for Translational Research “Stress & Immunity”, Department of Anesthesiology, LMU University Hospital Munich, Munich, Germany
Interests: allostatic load; stress-modulated immune responses; extreme environments; human space exploration

Special Issue Information

Dear Colleagues,

Activation of stress response systems such as the autonomic nervous system (ANS) and hypothalamic–pituitary–adrenal (HPA) axis is imperative for survival and adaptation. Since Hans Selye published his first manuscript on the general adaptation syndrome, stress research has provided insights into how the ANS and HPA axis interact and modulate key immune functions, yet much remains to be discovered. Chronic exposure to stressors together with unhealthy lifestyle factors, such as a lack of good-quality sleep, reduces coping capacity. The resulting chronic allostatic load and activation of stress response systems can greatly affect immunity towards all types of pathogens and may lead to immune dysfunction, hypersensitivity or autoimmune disease.

In this Special Issue, we welcome research articles as well as reviews covering recent advances in stress-modulated innate and adaptive immune functions, molecular and cellular mechanisms as well as integrative physiology and stress biomarker research. We also encourage contributions from research on extreme environments/earth-bound space flight analogues employing stressors such as isolation and confinement.

Dr. Judith-Irina Buchheim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psychoneuroimmunology
  • immunity
  • stress-modulated immune response
  • autoimmunity
  • hypersensitivity
  • stressors
  • environmental stress
  • allostatic load
  • autonomic nervous system (ANS)
  • hypothalamic–pituitary–adrenal (HPA) axis

Published Papers (1 paper)

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Research

21 pages, 2586 KiB  
Article
Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors
by Silvana Miranda, Randy Vermeesen, Wilhelmina E. Radstake, Alessio Parisi, Anna Ivanova, Sarah Baatout, Kevin Tabury and Bjorn Baselet
Int. J. Mol. Sci. 2023, 24(23), 16943; https://doi.org/10.3390/ijms242316943 - 29 Nov 2023
Cited by 1 | Viewed by 816
Abstract
The space environment will expose astronauts to stressors like ionizing radiation, altered gravity fields and elevated cortisol levels, which pose a health risk. Understanding how the interplay between these stressors changes T cells’ response is important to better characterize space-related immune dysfunction. We [...] Read more.
The space environment will expose astronauts to stressors like ionizing radiation, altered gravity fields and elevated cortisol levels, which pose a health risk. Understanding how the interplay between these stressors changes T cells’ response is important to better characterize space-related immune dysfunction. We have exposed stimulated Jurkat cells to simulated space stressors (1 Gy, carbon ions/1 Gy photons, 1 µM hydrocortisone (HC), Mars, moon, and microgravity) in a single or combined manner. Pro-inflammatory cytokine IL-2 was measured in the supernatant of Jurkat cells and at the mRNA level. Results show that alone, HC, Mars gravity and microgravity significantly decrease IL-2 presence in the supernatant. 1 Gy carbon ion irradiation showed a smaller impact on IL-2 levels than photon irradiation. Combining exposure to different simulated space stressors seems to have less immunosuppressive effects. Gene expression was less impacted at the time-point collected. These findings showcase a complex T cell response to different conditions and suggest the importance of elevated cortisol levels in the context of space flight, also highlighting the need to use simulated partial gravity technologies to better understand the immune system’s response to the space environment. Full article
(This article belongs to the Special Issue Inflammatory Responses and Immunity under Stress)
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