Leukemias: State-of-the-Art Molecular Pathogenesis and Influence of the Microenvironment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 April 2024 | Viewed by 3269
Special Issue Editors
Interests: diagnostic marker; genetics diagnostics; pediatrics; acute lymphoblastic leukemia
Interests: pediatric acute leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; lymphoma; immunophenotype; immunotherapy
Special Issue Information
Dear Colleagues,
Structural and submicroscopic chromosomal aberrations are inextricably linked to leukemia pathogenesis. It is suggested that many of these alterations occur along with other genetic changes to cause the disease. While genomic aberrations undergo leukemogenesis, the bone marrow microenvironment is being increasingly put forward as a factor of leukaemia progression, treatment resistance, and disease relapse. Recent studies have already identified recurrent mutations in the genes that regulate tumor cell–microenvironment interactions required for tumor cell growth; however, it is not clear how leukemic cells bring about modifications in the microenvironment.
Understanding how these cooperative genetic alterations and microenvironments affect cell proliferation and differentiation is essential for further therapy improvements. Analysis of the genetic and epigenetic abnormalities of leukemia cells allows us to establish potential targets for clinical intervention and novel treatment methods. Hopefully, it will soon be possible for patients diagnosed with leukemia to receive individualized treatment based on the genetic characteristics of their malignant cells. For this to be achievable, it is necessary to search for new alterations that may influence survival and relapse rates, and investigate the regulatory mechanisms associated with leukaemia–bone marrow niche interactions.
Dr. Monika Lejman
Dr. Maciej Niedźwiecki
Guest Editors
Manuscript Submission Information
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Keywords
- leukemia
- leukemia microenvironment
- target therapy
- molecular mechanisms
- genetic abnormalities
- gene expression
